This study was conducted to examine the mechanism for arachidonic acid (AA) regulation of steroidogenic acute regulatory (StAR) protein expression and the relationship between AA and cAMP in hormone-induced steroidogenesis. Dibutyryl cyclic AMP (Bt(2)cAMP)-stimulated MA-10 Leydig cells were treated with AA and/or the phospholipase A(2) inhibitor, dexamethasone. Dexamethasone significantly reduc...

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While both the quantity and quality of food ingested are potent regulators of whole body protein metabolism in ruminants, little data are available on responses across a wide range of intakes. The current study examined the responses in whole body protein flux (PrF) to such intake changes and compared these with the responses across the hind-quarters (in a companion study). Six growing sheep (6...

Telomere maintenance is essential for the unlimited proliferative potential of human cells, and hence immortalization. However, a number of tumors, tumor-derived cell lines and in vitro immortalized cell lines have been described that do not express detectable telomerase activity. These lines utilize a mechanism, termed Alternative Lengthening of Telomeres (ALT), to provide telomere maintenance...

Abstract Background: Haemophilia A (HA) is an X-linked bleeding disorder caused by the absence or reduced activity of coagulation factor VIII (FVIII). Coagulation factors are a group of related proteins that are essential for the formation of blood clots. The aim of this study was to genotype the coagulation factor VIII gene mutations using Inverse Shifting PCR (IS-PCR) in an Iranian family ...

Afforestation is an essential strategy for erosion control. The objective of this study was to determine the soil quality index (SQI) in established afforested areas different ages control Erzurum, Turkey. Three were selected as plots considering their establishment periods: + 40 years old (AA>40), 10–40 (AA10–40), and less than 10 (AA<10). Forty samples taken each plot area over 0–15 15–30 cm ...

study was undertaken to establish the optimum dietary indispensable amino acid (IAA) profile for yellow fin seabream broodstock based on the amino acid (AA) profile of broodstock, eggs and larvae of Acanthopagrus latus. Three isonitrogenous (40%) and isolipid (20%), named diets 1, 2 and 3 were formulated with different ratios of total essential amino acids per total non-essential amino acid...

Previous efforts to simulate mammary metabolism have focused on energy, mostly considering amino acids (AA) in aggregate. The main objective of this work was to build a model of mammary metabolism, based on data from arterio-venous difference studies, which considered AA in sufficient detail to predict yields of milk solids. The model contains 19 state variables and considers the removal of 37 ...

Due to their high content in esterified arachidonic acid (AA), macrophages provide large amounts of eicosanoids during innate immune reactions. Bacterial lipopolysaccharide (LPS) is a poor trigger of AA mobilization in macrophages but does have the capacity to prime these cells for greatly increased AA release upon subsequent stimulation. In this work, we have studied molecular mechanisms under...