Background: Esophageal cancer remains one of the deadliest cancers with an overall 5-year survivalrate estimated to be less than 18%. Squamous cell carcinoma esophagus is predominanthistology in cervical and upper middle thirds thoracic esophagus, whereasadenocarcinoma predominates distal esophagus. Lymph node involvement number oflymph metastases are important prognostic factorsMaterials Metho...

BACKGROUND AND STUDY AIMS It has been postulated that the endoscopic ablation of Barrett's esophagus can lead to complete eradication of the disease. This study was undertaken to evaluate the efficacy of endoscopic eradication therapy for Barrett's esophagus and the rates of recurrence of intestinal metaplasia. PATIENTS AND METHODS As part of an initial randomized controlled trial, patients w...

CONTEXT Barrett's esophagus (BE) is characterized by intestinal metaplasia in the distal esophagus and is classified as short-segment (<3 cm - SSBE) or long-segment (>3 cm - LSSBE). It is suggested that LSSBE is associated with more severe esophageal motor abnormalities and increased acid exposure time than SSBE. OBJECTIVE To evaluate the prevalence of esophageal manometriy abnormalities and ...

Baseline impedance (BI) measurement can be used to evaluate the status of the esophageal mucosa integrity. We hypothesized that impaired esophageal mucosal integrity may play a causative role in patients with nongastroesophageal reflux disease (non-GERD)-related noncardiac chest pain (NCCP). This retrospective study analyzed 24-hour multichannel intraluminal impedance-pH testing data from 77 pa...

BACKGROUND/AIMS Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein with vital function during human embryogenesis in terms of cellular growth and migration. Although it has minimum and undetectable expression in human adult tissues, it is highly expressed in various types of cancer. Few studies have recommend application of IMP3 expression to diagnose challengin...

At the gastroesophageal junction, most vertebrates possess a functional lower esophageal sphincter (LES) which may serve to regulate the passage of liquids and food into the stomach and prevent the reflux of gastric contents into the esophagus. Snakes seemingly lack an LES and consume meals large enough to extend anteriorly from the stomach into the esophagus thereby providing the opportunity f...

Barrett esophagus was found in seven members of a single family. Two of these patients also had adenocarcinoma of the gastroesophageal junction. Among family members who did not have Barrett epithelium, one had esophageal ulcerations with dysplasia in squamous epithelium and another had an esophageal stricture. The pattern of involvement suggests autosomal dominant inheritance of Barrett esopha...

Diseases of the Esophagus is an official journal of the International Society for Diseases of the Esophagus (ISDE), which was founded in 1979 as a membership-supported society. This international journal covers all aspects of the esophagus etiology, investigation and diagnosis, and both medical and surgical treatment. The Journal includes primary research papers, short reports, commissioned rev...