Corrosive esophageal burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment in acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and pla...

BACKGROUND/AIMS The impact of aging on esophageal motility is not completely understood. This study aims at assessing 1) whether degeneration of esophageal body motility occurs with age and 2) whether this development is influenced by gastroesophageal reflux disease (GERD). METHODS 326 consecutive patients with symptoms of GERD underwent a diagnostic work-up including a water-perfused esophag...

OBJECTIVE To describe the early complications of esophageal replacement with colon in children. METHODS Descriptive cross-sectional study from 2005 to 2011 in pediatric patients diagnosed with alkali intake, esophageal atresia or esophageal injury traumatic esophageal replacement handled via retrosternal colon. Descriptive statistical analysis using SPSS 20.0. RESULTS We included 19 esophag...

PURPOSE CC chemokine receptor 7 (CCR7) plays a critical role in the migration of activated dendritic cells to regional lymph nodes. Recent studies have shown that CCR7 is involved in metastasis in some malignant diseases. The role of CCR7 in esophageal squamous cell carcinoma (SCC) has not yet been clarified. EXPERIMENTAL DESIGN We performed reverse transcription-PCR analysis for CCR7 in 20 e...

introduction: foreign body ingestion is common among children and more common in boys and in children under the age of 3. it can present with a wide variety of symptoms like dysphagia and drooling or symptoms related to the upper aerodigestive tract.   case report: a 20-month-old male presented with refractory croup and poor feeding since 2 weeks. bronchoscopy and esophagoscopy was performed du...

esophageal cancer is the eighth most ordinary cancer and the sixth most common cancer between the males and ninth for females in the world; its major and effective treatment is external radiotherapy. this type of cancer can be found in different areas of esophagus including cervical, upper, middle and lower esophagus. in this treatment, healthy tissues such as the trachea, spine and sternum and...

background: the most common congenital abnormality of esophagus is esophageal atresia (ea) that can occur with or without tracheoesophageal fistula. other associated anomalies are the leading cause of death in these patients. the present study aimed to evaluate the main complication, outcomes and cause of death in neonate with ea repaired in amirkola children’s hospital (ach), iran within a 13 ...

conclusions the level of two cp and meld scores and their individual variables in two groups of patients with esophageal and gastric varices bleeding were not significantly different. on the other hand, re-bleeding rate was not different between these two groups. results among 34 understudied patients, 12 patients (8 males) had gastric varices and 22 patients (15 males) had esophageal varices. ...

Eosinophilic esophagitis is characterized by increased infiltration and degranulation of eosinophils in the esophagus. Whether eosinophil-derived cationic proteins regulate esophageal sensory nerve function is still unknown. Using synthetic cationic protein to investigate such effect, we performed extracellular recordings from vagal nodose or jugular neurons in ex vivo esophageal-vagal preparat...

Esophageal hypersensitivity is important in gastroesophageal reflux disease (GERD) patients who are refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. Esophageal sensitivity to ...