on tall fescue pastures (West et al., 1988; Clay, 1993; Siegel and Bush, 1996), as well as controlling plant disTall fescue (Festuca arundinacea Schreb.) is an important cooleases (Latch, 1997). A variety of alkaloids, N-containing season perennial forage naturally infected with an endophyte, Neotyphodium coenophialum Glenn, Bacon, & Hanlin, which produces ring structures, are produced in the t...

Forty-two patients with elevated serum prolactin were treated in a randomized, open-label trial with the conventional ergot bromocriptine, or a new ergot pergolide. Before treatment, the patients underwent thorough endocrine evaluation and computed tomographic scan. All patients had prolactin levels greater than 25 ng/ml, and 27 patients had a pituitary mass. Follow-up studies performed after 6...

Tall fescue is productive and well adapted to the soils and climate in a region commonly referred to as the “fescue belt”, which overlays the transition zone between the temperate northeast and subtropical southeast. Persistence of the grass under low input management is attributed to a fungal endophyte that infects most fescue plants and produces alkaloids that impart tolerance to heat, drough...

Ergotism is a toxic condition resulting from overexposure to the ergot compounds produced by various fungi of the genus Claviceps. Traditionally, such exposure was due to ingestion of infected grains, but long-term or excessive use of medications containing ergot derivatives or drug-drug interactions between these medications can result in ergotism. Ergotamine, typically used to treat migraine,...

A putative dimethylallyltryptophan synthase gene, fgaPT2, was identified in the genome sequence of Aspergillus fumigatus. fgaPT2 was cloned and overexpressed in Saccharomyces cerevisiae. The protein FgaPT2 was purified to near homogeneity and characterized biochemically. This enzyme was found to convert L-tryptophan to 4-dimethylallyltryptophan, a reaction known to be the first step in ergot al...

Nicergoline is a semisynthetic ergot derivative and has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions, both in the brain and in the periphery. It is in clinical use for over three decades in over fifty countries for conditions such as cerebral infarction, acute and chronic peripheral circulation disorders, vascular dementia, and Alzhe...

Sorghum ergot in India is caused by Claviceps africana and C. sorghi. The distributions of these two species in India is not known. Eighty-nine sorghum ergot isolates were cultured from young sphacelia obtained from male sterile sorghum plants artificially inoculated using inoculum collected in the field. Based on cultural characteristics, the isolates were separated into two groups which diffe...