نتایج جستجو برای: erg
تعداد نتایج: 7132 فیلتر نتایج به سال:
Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers. Its relevance in castration-resistant prostate cancer (CRPC) remains controversial as ERG is not expressed in some TMPRSS2-ERG androgen-independent xenograft models. However, unlike these models, CRPC patients have an increasing prostate-specific antigen, indicating ac...
سابقه و هدف: این مطالعه به منظور بررسی اختلال راه عصب بینایی چشم با آزمایش الکترورتینوگرام (ERG) در بیماران مصرف کننده سیکلوسپورین ارجاع شده به کلینیک بصیر طی سالهای 95-94 انجام شد. روش بررسی: در این مطالعه مورد- شاهدی، 50 بیمار مصرف کننده سیکلوسپورین مراجعه کننده به کلینیک بصیر در سال 1394-1395 به صورت در دسترس انتخاب شده و تحت آزمون الکترورتینوگرافی قرار گرفتند. نتایج این آزمون شامل ولتاژ و ف...
The ERG gene belongs to the ETS family of transcription factors and has been found to be involved in atypical chromosomal rearrangements in several cancers. To gain insight into the oncogenic activity of ERG, we compared the gene expression profile of NIH-3T3 cells stably expressing the coding regions of the three main ERG oncogenic fusions: TMPRSS2/ERG (tERG), EWS/ERG and FUS/ERG. We found tha...
To the Editor: The recent article by Mosquera et al. reports TMPRSS2-ERG fusions in 46% of 100 trans-rectal biopsies of the prostate (TRBP) from prostate-specific antigen screened men in the United States (1) and compares this to the lower prevalence of ERG translocations in cancer detected incidentally on trans-urethral resection of the prostate (TURP). We agree with the authors that the lower...
Our purpose was to develop a new pharmacological approach for the treatment of prostate cancer (PCa), the most common neoplasia in men. Recently, we developed siRNA against the fusion oncogene TMPRSS2-ERG found in 50% of patients and showed an antitumoral activity in animal model. Herein, we want to compare or combine the developed siRNA to flutamide (FLU), one of the gold-standard treatment of...
Direct modulation of gene expression by targeting oncogenic transcription factors is a new area of research for cancer treatment. ERG, an ETS-family transcription factor, is commonly over-expressed or translocated in leukaemia and prostate carcinoma. In this work, we selected the di-(thiophene-phenyl-amidine) compound DB1255 as an ERG/DNA binding inhibitor using a screening test of synthetic in...
PURPOSE A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analyses were performed. Microscopic investigations were done at two different age...
PURPOSE This study evaluated the validity of ergometer tests against the criterion of on-water rowing and determined the reliability of field measurements by comparing results between ergometer (ERG) and on-water (OW) tests. METHODS Seven male rowers completed incremental tests on a Concept2 rowing ergometer and in a single scull. Average power output, oxygen consumption (VO2), heart rate (HR...
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