نتایج جستجو برای: erbb1

تعداد نتایج: 434  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Vincent Prevot Carlos Rio Gyeong J Cho Alejandro Lomniczi Sabine Heger Craig M Neville Nadia A Rosenthal Sergio R Ojeda Gabriel Corfas

The initiation of mammalian puberty requires the activation of hypothalamic neurons secreting the neuropeptide luteinizing hormone-releasing hormone (LHRH). It is thought that this activation is caused by changes in trans-synaptic input to LHRH neurons. More recently, it has been postulated that the pubertal increase in LHRH secretion in female animals also requires neuron-glia signaling mediat...

Journal: :Breast care 2008
Nadia Harbeck Volker Heinemann Sibylle Loibl Michael Untch

mic ATP-binding site of the receptor TK, lapatinib blocks receptor phosphorylation and prevents subsequent downstream signaling. This is in contrast to trastuzumab which acts primarily by stimulating antibody-dependent cellular cytotoxicity (ADCC) [8, 9]. The rationale for the development of a dual inhibitor is threefold: Firstly, the combined blockage of two receptors involved in tumor prolife...

Journal: :Glia 2005
George M Smith Celia Strunz

After injury to the adult central nervous system (CNS), numerous cytokines and growth factors are released that contribute to reactive gliosis and extracellular matrix production. In vitro examination of these cytokines revealed that the presence of transforming growth factor-beta1 (TGF-beta1) and epidermal growth factor (EGF) greatly increased the production of several chondroitin sulfate prot...

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