Estrogen replacement therapy in postmenopausal women is associated with a reduction in colorectal cancer risk, potentially via interactions between 17B-estradiol (E2) and the estrogen receptors (ER) A and B. To study the role of E2 in intestinal tumor inhibition, we separately crossed C57BL/ 6J-Min/+ (Min/+) mice with Era and Erb mice to generate ER-deficient Min/+ progeny. We found an increase...

Assessing the energy performance of existing residential buildings (ERB) has been identified as key to improving building efficiency and reducing associated greenhouse gas emissions in Canada. However, identifying optimal retrofit packages requires a significant amount knowledge modelling, it is time-consuming laborious process. This paper proposed data-driven framework that combines machine le...

The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes. The circadian rhythm is an endogenous mechanism, which generates entrainable biological changes that follow a 24-hour period. It regulates a number of physiological processes, including sleep/wakeful cycles and feeding behaviors...

The two known estrogen receptors, ERa and ERb, mediate the effects of estrogen in all target tissues, including blood vessels. We have shown previously that estrogen inhibits vascular injury response to the same extent in female wild-type (WT), ERa knockout (ERaKOCH), and ERb knockout (ERbKOCH) mice. We generated mice harboring disruptions of both ERa and ERb genes (ERa,bKOCH) by breeding and s...

Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circ...

BACKGROUND Synovial sarcoma is a malignant mesenchymal tumor composed of varying proportions of spindle and epithelial cell components. Because of the histologic and immunohistochemical similarity of synovial sarcoma to epithelial carcinomas, we hypothesized that the human epithelial growth factor receptor 2 (C-erb-B2, also termed HER2/neu) may contribute to the tumor phenotype and provide a ne...

BACKGROUND Breast cancer grows in a hormone-rich environment which influences its biological features and thus, ultimately, its clinical behavior. Circulating hormone levels were measured in premenopausal and postmenopausal breast cancer patients prior to surgery, and correlated with all available clinical and biological features of the tumors and with serum tumor marker levels. MATERIALS AND...

OBJECTIVE Left ventricular (LV) dysfunction after trastuzumab treatment in erb-2 breast cancer cases has been fully investigated. However, there is not enough data about the effect of trastuzumab treatment on right ventricular (RV) functions. This study is designed to evaluate the right heart changes by performing echocardiography after trastuzumab treatment in patients with erb-2 breast cancer...

Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by my...

Objective Radiation-induced skin injury (RISI) remains a serious concern during radiotherapy. IL-10 is considered as an immune suppressive cytokine by inhibiting the secretion of proinflammatory cytokines in cells. The aim this study was to evaluate protective role Erb (IL10) 2 against ionizing radiation. Methods We fused Interleukin 10 (IL-10) dimer onto anti-epidermal growth factor receptor a...