Detailed dynamic kinetic models at the network reaction level are traditionally constructed using mechanistic enzymatic rate equations and a large number of kinetic parameters have to be determined under nonphysiological conditions in vitro. However, the validity of these parameters under in vivo conditions is doubtful and the rates equations are usually highly complex. Therefore, one of the ma...

The main objective of present research work is to formulate the Clopidogrel Fast Dissolving tablets. Clopidogrel, an antiplatelet drug, belongs to BCS Class-II and used to control Heart attack, Hypertension by inhibiting Platelet activation and aggregation .The Fast Dissolving tablets of Clopidogrel were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in di...

In this work, kinetics and thermodynamics of esterification reaction were studied. This research investigated the esterification reaction between methanol and acidified oil catalyzed by sulfonated cation exchange resin and proposed a new rate equation for consideration of kinetics of this reaction according to the Langmuir-Hinshelwood mechanism. Thermodynamics and kinetics parameters were calcu...

In this paper, we prove the H-theorem for generalized chemical kinetics equations. We consider following important physical examples of such a generalization: discrete models quantum kinetic equations (Uehling–Uhlenbeck equations) and Markov process (quantum random walk). that time means coincide with Boltzmann extremals all Liouville equation as well. This gives us an approach to select action...

There are still many open questions concerning the relationship between (steady) kinetic equations, random particle games designed for these equations, and transitions, e.g. to uid dynamics and turbulence phenomena. The paper presents some rst steps into the derivation of models which on one hand may be used for the design of e cient numerical schemes for steady gas kinetics, and on the other h...

We study a system of two nonlinear parabolic equations with cosymmetry and find a continuous family of equilibria with nonconstant spectrum. Basing on the finite-difference approach, we develop a numerical method for solving the partial differential equations and calculating the continuous family of non-cosymmetrical equilibria. An application of the proposed system to population kinetics is de...

Gene expression, signal transduction and many other cellular processes are subject to stochastic fluctuations. The analysis of these stochastic chemical kinetics is important for understanding cell-to-cell variability and its functional implications, but it is also challenging. A multitude of exact and approximate descriptions of stochastic chemical kinetics have been developed, however, tools ...

We consider a multidimensional model for the dynamic combustion of compressible reacting fluids formulated by the Navier Stokes equations in Euler coordinates. For the chemical model we consider a one way irreversible chemical reaction governed by the Arrhenius kinetics. The existence of globally defined weak solutions of the Navier-Stokes equations for compressible reacting fluids is establish...