An assay for epoxide hydrolase activity using benzo(a)-pyrene 4,5-oxide as substrate was modified in such a manner that it allowed the estimation of activities in native and in cultivated mitogen-stimulated human lymphocytes. Their specific activities were about 1000-fold lower than those of human or rat liver microsomes. In native lymphocytes of 28 subjects, the specific activities of epoxide ...

The production of aliphatic polyesters (via ROP cyclic esters) and polycarbonates ROCOP CO2/epoxide) is an important synthetic pathway for the biodegradable biocompatible polymers. study focuses on catalytic activity selectivity phenoxy-imine based zinc compounds esters (rac-LA -CL) carbon dioxide CHO/PO. monoligated bisligated have same coordination number (four) but differed from each other ...

The tumorigenicity of chrysene, (+)and (-)-frans-1,2-dihydroxy-1,2-dihydrochrysene (chrysene 1,2-dihydrodiol), and the ( + )and (—)-enantiomers of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides was assessed in two tumor models. A single topical application of 0.4 or 1.2 /¿mol of the chrysene derivatives on mouse skin followed by 25 weeks of promotion with 12-O-tetradecanoylphor...

Alkoxyamines of TEMPO usually dissociate thermally at >100 °C; however, room temperature homolysis, activated by visible light, occurs with benzimidazolequinone derivatives. 1,1’-Dimethyl-2,2’-bis{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-6-(trifluoromethyl)-1H,1’H-[5,5’-bibenzimidazole]-4,4’,7,7’-tetrone (CF3-Bis-TEMPO-Vis) is prepared in a 59% yield through NBS/H2SO4 oxidative demeth...

A series of binuclear aluminum complexes 1–3 supported by tridentate phenoxyimino-phenoxy ligands was synthesized and used as catalysts for the coupling reaction terminal epoxide with carbon dioxide. The complex 1, which is catalytically inactive toward CO2 itself, shows moderate activity in presence excess nucleophiles or organic bases at high temperature. In sharp contrast to bifunctional 2 3...

The metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) by prostaglandin synthetase and cytochrome P-450-dependent monooxygenases was studied using enriched fractions of Clara cells and alveolar type II cells from rat lung. Arachidonic acid-fortified fractions enriched in Clara cells and alveolar type II cells metabolized BP-7,8-diol to the 7,10/8,9-tetrol of benzo(a...