Sensitization and exposure to the allergenic fungus Alternaria alternata has been associated with increased risk of asthma and asthma exacerbations. The first cells to encounter inhaled allergens are epithelial cells at the airway mucosal surface. Epithelial barrier function has previously been reported to be defective in asthma. This study investigated the contribution of proteases from Altern...

BACKGROUND Lungs develop from the fetal digestive tract where epithelium invades the vascular rich stroma in a process called branching morphogenesis. In organogenesis, endothelial cells have been shown to be important for morphogenesis and the maintenance of organ structure. The aim of this study was to recapitulate human lung morphogenesis in vitro by establishing a three dimensional (3D) co-...

background functional constipation (fc) and constipation-predominant irritable bowl syndrome (cibs)are two main subtypes of constipation that can be distinguished by the rome ii criteria. measuring colonic transit time (ctt) is an easy and cost effective way to evaluate constipation. this study was conducted to compare the ctt in patients with fc and cibs. materials and methods those patients w...

background and objectives: the aim of this study was to investigate the significance of multiple-mutations in the katg gene, predominant nucleotide changes and its correlation with high level of resistance to isoniazid in mycobacterium tuberculosis isolates that were randomly collected from sputa of 42 patients with primary and secondary active pulmonary tuberculosis from different geographic r...

Background: Oral potentially malignant disorders (OPMDs) comprise any disorders, tumors, in addition to microscopic alterations that have a risk of development cancers the mouth. When epithelial dysplasia is detected an oral lesion, it termed as precancerous lesion. Finding: Several changes color or thickness normal mucosa might be during clinical diagnosis lesions. Leukoplakia cavity name for ...

Paying attention to the views of the elderly and identifying their understanding of old age can be great help for proper consideration about their needs and problems. The purpose of this study was to understand the predominant experience of elderly people of aging. Hermeneutics phenomenology was used to collect data, and the van Manen's method was implemented to analyze those data. The required...

Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype and potential risk. The purpose of this study was to develop a mathematical mo...