Epileptic seizures constitute a serious neurological condition for patients and, if untreated, considerably decrease their quality of life. Early and correct diagnosis by semiological seizure analysis provides the main approach to treat and improve the patients’ condition. To obtain reliable and quantifiable information, medical professionals perform seizure detection and subsequent analysis us...

Predicting the epileptic seizure is challenging biomedical problem. EEG signal includes enormous information. Few relevant parameters are expected in the field of recognition and diagnostic purposes. Seizure detection and classification system has been designed and developed. The system uses computer based procedures to detect seizure and classified normal and abnormal subjects. Intelligent com...

Mechanisms underlying seizure cessation remain elusive. The Lennox-Gastaut syndrome, a severe childhood epileptic disorder, is characterized by episodes of seizure with alternating epochs of spike-wave and fast run discharges. In a detailed computational model that incorporates extracellular potassium dynamics, we studied the dynamics of these state transitions between slow and fast oscillation...

Accurate localization of the epileptic seizure onset zones (SOZs) is crucial for successful surgery, which usually depends on the information obtained from intracranial electroencephalography (IEEG) recordings. The visual criteria and univariate methods of analyzing IEEG recordings have not always produced clarity on the SOZs for resection and ultimate seizure freedom for patients. Here, to con...

Introduction: The relationship between epilepsy and psychiatric disorders is an important issue for researchers which affect the quality of life among patients. Psychiatric comorbidities such as depression and anxiety, is associated with negative course of epilepsy, more complications, poor drug tolerance and higher mortality rates. In addition to the epileptic patients, their families are also...

Many studies have focused on the nonlinear analysis of electroencephalography (EEG) mainly for the characterization of epileptic brain states. It is assumed that at least two states of the epileptic brain are possible: the interictal state characterized by a normal apparently random, steady-state EEG ongoing activity; and the ictal state that is characterized by paroxysmal occurrence of synchro...

Abstract Background Recent studies suggest potential roles of immune response in the pathophysiology epilepsy. Anti-seizure medications (ASMs) are known to have side effects drug eruption caused by responses. A few reports adults demonstrated disappearance seizures after an ASM episode. In this paper, we described 2 cases childhood absence epilepsy (CAE) who showed seizure ethosuximide (ESM) er...

Objective: Epileptic seizures may cause skeletal muscle injury and memory dysfunctions. The present study was aimed to investigate the possible protective effects of exercising prior seizure on seizure-induced oxidative in brain. Materials Methods: Sprague-Dawley male rats were assigned as non-exercise (n=16) exercise groups (n=16). Following a 3-day training, protocol (30 min) performed treadm...

Epilepsy is common neurological diseases, affecting about 0.6-0.8 % of world population. Epileptic patients suffer from chronic unprovoked seizures, which can result in broad spectrum of debilitating medical and social consequences. Since seizures, in general, occur infrequently and are unpredictable, automated seizure detection systems are recommended to screen for seizures during long-term el...

BACKGROUND Seizures are common in dogs and can be caused by non-epileptic conditions or epilepsy. The clinical course of newly diagnosed epilepsy is sparsely documented. The objective of this study was to prospectively investigate causes for seizures (epileptic and non-epileptic) in a cohort of dogs with new-onset untreated seizures, and for those dogs with newly diagnosed epilepsy to investiga...