OBJECTIVE To examine whether there is an association between the quality of epilepsy care, as measured by the Quality and Outcomes Framework of the 2004 General Practitioner contract for England, practice population deprivation status and epilepsy-related emergency hospitalisation. METHODS Linear regression analysis was used to examine the association between the proportion of epilepsy-treate...

BACKGROUND The aim of this study was to determine the prevalence and nature of self-perceived seizure precipitants in epilepsy patients, and evaluate whether anxiety level, depression, or health locus of control influence self-perception of seizure precipitants. METHODS Adults aged 18 and older who had epilepsy for at least 1 year were recruited in either the inpatient epilepsy monitoring uni...

Epilepsy seizure detection in Electroencephalogram (EEG) is a major issue in the diagnosis of epilepsy and it can be considered as a classification problem. According to the particular property of EEG, a novel method based on sparse representation is proposed for epilepsy detection in this paper. Classification accuracy, robustness on noisy data and parameters (the size of dictionary and the nu...

Long term video electroencephalography (EEG) in epilepsy monitoring units (EMU) is used to diagnose and treat patients with epilepsy. Injury occurs in the EMU, including reports of death. No standardized patient safety protocols exist. Our objective is to determine the frequency and contributing factors to injury in the EMU. We reviewed medical records and video EEG of patients with epilepsy ad...

INTRODUCTION Epilepsy is a devastating neurological disorder affecting the neuropsychological functioning of the sufferers. AIM AND DEVELOPMENT This paper reviews the crucial factors associated with the cognitive status of people with epilepsy. These factors include seizure type and other medical variables such as age of onset, seizure frequency, and seizure history. The effect of these facto...

Epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. It has been shown that each seizure has a depressing effect on the following seizure. Thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. In this study, the role of adenosine A1 receptors in ...

Reasons for failed temporal lobe epilepsy surgery remain unclear. Temporal plus epilepsy, characterized by a primary temporal lobe epileptogenic zone extending to neighboured regions, might account for a yet unknown proportion of these failures. In this study all patients from two epilepsy surgery programmes who fulfilled the following criteria were included: (i) operated from an anterior tempo...

the new-aeds, whose developments were motivated following the discovery of the valproate and its marketing in the u.s in 1978, have presented more therapeutic options. there are approximately twenty four fda-approved antiepileptic drugs for use in patients with epilepsy, five of which were identified and have come on to the market between 2009 and 2012. the new-aeds are of interest, not due to ...

PURPOSE In epilepsy, many studies were focus on apoE gene polymorphism and found APOE epsilon4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure. METHODS A total of 60 epileptic patients and 28 subjects with no evidence ...

Temporal lobe epilepsy is often medically refractory and new targets for intervention are needed. We used a mouse model of temporal lobe epilepsy, on-line seizure detection, and responsive optogenetic intervention to investigate the potential for cerebellar control of spontaneous temporal lobe seizures. Cerebellar targeted intervention inhibited spontaneous temporal lobe seizures during the chr...