In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative ...

Distribution and prevalence of various species of dermatophytes are not the same in different areas of the world. The aim of the present study was epidemiologic evaluation of dermatophytic infections in our area. A retrospective epidemiologic study was carried out and all patients with dermatophyte positive smears identified at the Referral Center of Southwest Iran located in the city of Ahvaz ...

Species of dermatophytes are classified into three anamorphic (asexual) genera, Epidermophyton, Microsporum, and Trichophyton. Conventional methods used to identify dermatophytes are often lengthy and may be inconclusive because of atypical microscopic or colony morphology. Based on the internal transcribed spacer 1 (ITS-1) and ITS-2 sequences of the rRNA genes, an oligonucleotide array was dev...

PURPOSE Fungal infections are one of the most common skin infections. Athletes, especially in contact sports such as wrestlers are the group at risk of fungal skin infections (FSI). The aim of this study was to determine prevalence of FSI and some effective factors in wrestlers in Tehran, Iran. METHODS This study was a cross-sectional descriptive study which was conducted in 2009 and subjects...

The objective of this research was to extend the Vitek MS fungal knowledge base version 2.0.0 to allow the robust identification of clinically relevant dermatophytes, using a variety of strains, incubation times, and growth conditions. First, we established a quick and reliable method for sample preparation to obtain a reliable and reproducible identification independently of the growth conditi...

BACKGROUND Since ancient time, increased interest has been witnessed in the use of an alternative herbal medicine for managing, and the treatment of fungal diseases worldwide. This may be connected to the cost and relative toxicities of the available antifungal drugs. It has been a known tradition practiced in the northern part of Nigeria that parents and teachers use the white latex of Calotro...

Vanbreuseghem (1) recently described a selective procedure for isolating keratinophilic fungi from soil. The method extends the work of Karling (2), who first used keratin in various forms as bait for the isolation of chytrids from soil and water. Vanbreuseghem placed hair filaments upon the surface of moistened soil in which Trichophyton mentagrophytes (Ctenomyces interdigitalis), T. rubrum an...

A rapid two-step DNA extraction method and a multiplex PCR for the detection of dermatophytes in general and Trichophyton rubrum specifically were developed and evaluated with DNA extracted from pure cultures and from clinically diseased nails. DNA from the following dermatophytes was used: Epidermophyton floccosum, Microsporum audouinii, Microsporum canis, Microsporum gypseum, Microsporum nanu...

Skin lesions caused by dermatophytes are classified depending on the infected skin structure: surface layer of cutis, fur layer, clutches or nails. Surface mycoses are caused by dermatophytes: Epidermophyton, Microsporum and Trichophyton species (also important are Malassezia spp., Candida spp., and Trichosporon). Skin is the target tissue for fungal infections if the epithelial layer is damage...

BACKGROUND Onychomycosis is a nail disorder associated with aesthetic problems, discomfort, physical injury and loss of dexterity. The purpose of the present study was to isolate and identify the causative fungi of onychomycosis in 2402 patients in Kermanshah Province, western Iran in 1994 to 2010. METHODS Mycologic assessment was carried out by standard methods including either microscopic o...