background: despite almost the three decades passed since the chemical attacks of iraqi’s army against the iranian troops, some veterans are still suffering from long-term complications of sulfur mustard (sm) poisoning, including certain skin complaints specially dryness, burning, and pruritus. we thus aimed to evaluate the skin’s water and lipid content in patients with a disability of >25% du...

toxic epidermal necrolysis is a potentially life-threatening disease, which needs necessary treatment. we present a 12 years old female who was a known case of idiopathic generalized tonic-clonic convulsion and presented with fever, diarrhea and generalized erythematous eruption after 2 weeks of being under treatment with maintenance doses of lamotrigine (ltg) and valproate (vpa). the eruption ...

introduction: epidermoid cysts are rare, slow‑growing, benign, developmental cysts, which are derived from abnormally situated ectodermal tissue. epidermoid cysts of the floor of the mouth represent <0.01% of all oral cysts. so far, only a few cases have been reported. case report: hereby, we present a case of a giant sublingual epidermoid cyst, which was completely asymptomatic upon presentati...

Muscle cells of the ascidian larva originate from three different lines of progenitor cells, the B-line, A-line and b-line. Experiments with 8-cell embryos have indicated that isolated blastomeres of the B-line (primary) muscle lineage show autonomous development of a muscle-specific enzyme, whereas blastomeres of the A-line and b-line (secondary) muscle lineage rarely develop the enzyme in iso...

Terrestrial mosses have been used for more than 50 years to monitor air pollution. We argue, however, that their value as biomonitors is based on two widespread but partially erroneous assumptions concerning morphological structure (the structural myth) and physicochemical characteristics myth). The myth consists of the oversimplification moss structure. recognizes high cation exchange capacity...

Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...

Histone lysine-specific demethylase 1 (LSD1) is a key epigenetic enzyme known to be involved in lineage-specific development and cell differentiation. Through its function, LSD1 represses crucial differentiation genes preserves progenitor-like fates. As such, frequently overexpressed human malignancies, portending poor prognosis cancers including cutaneous squamous carcinoma (cSCC). inhibitors ...

Psoriasis is a chronic inflammatory disease characterized by immune cytokine-stimulated epidermal hyperproliferation. The epidermis breaks from non-lesional (healthy) state to new steady with higher ratio of each cell type. During this process, T derived cytokines not only cause an increase in proliferation but also alter how these cells divide. We developed agent-based model understand psorias...

Background: Despite the meager role of the masculine agent in infertility (the low number of infertile men than women infertile), there are men whose wives are unable to become pregnant due to the absence of sperm, decreased numbers of sperm or lack of sufficient motile sperm. Utilizing donated sperm is a method that enables these families to have children. The use of this method prompts us to ...

background: several influential factors such as transcription factors and intracellular signaling components are involved in differentiation of stem cells into a specific lineage. p15 and p16 proteins are among these factors. accumulating evidences has introduced the epigenetic as a master regulator of these factors during lineage specification. the main objective of this study is to determine ...