The organiser regret that in the original publication of this abstract author listing was given incorrectly. correct is as now above. organisers would like to apologise for any inconvenience caused. 12P efficacy EGFR tyrosine kinase inhibitors and its clinical prognostic factors lung adenocarcinoma patients harboring different types mutations: Real-world dataAnnals OncologyVol. 33PreviewLung ca...

Binding of ouabain to Na(+)/K(+)-ATPase activates tyrosine phosphorylation of the epidermal growth factor receptor (EGFR), Src, and p42/44 mitogen-activated protein kinases (MAPKs) in both cardiac myocytes and A7r5 cells. Here, we explored the roles of Src and the EGFR in the ouabain-invoked pathways that lead to the activation of MAPKs. Exposure of A7r5 and LLC-PK1 cells to ouabain caused a do...

The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, have shown promising therapeutic efficacy in nonsmall cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor- (EGFR-) activating mutation. However, the inevitable recurrence resulting from acquired resistance has limited the clinical improvement in therapy outcomes...

Mutations of the epidermal growth factor receptor (EGFR) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutated EGFR. Rapid and accurate EGFR mutation testing is essential for patient selection and establishing targeted therapies w...

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility, and differentiation. The dysregulated activation of the receptor is often implicated in human cancers. EGFR is synthesized as a single-pass transmembrane protein, which consists of an extracellular ligand-binding domain and an intracellular kinase domain separate...

Background. Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective in patients with nonsmall cell lung cancer with epidermal growth factor receptor (EGFR) mutation, EGFR-TKIs have a risk of inducing fatal interstitial lung disease (ILD). The selection of chemotherapy based on the EGFR mutation status is recommended, however, the frequency of EGFR mutation...

Over the last 10 years, the approach to the treatment of cancer has changed significantly due to an improved understanding of the processes that regulate tumor growth and development. Targeted strategies act against various neoplasms, alone or in combination with conventional therapy, while avoiding most of the toxicities induced by standard chemotherapy and radiotherapy. Promising targets incl...

Abstract Heparin-Binding EGF-like Growth Factor (HB-EGF) is a ligand for the Epidermal Receptor (EGFR), tyrosine kinase receptor which promotes cell proliferation and migration. In epithelium of lung, HB-EGF an important factor wound repair, however little known about effects on viral infection in vivo. Literature suggests that human alveolar epithelial lines, EGFR cofactor Influenza A infectio...