A traditional Chinese herbal medicine, Kampo medicine, maoto, has been widely used in the treatment of febrile symptoms caused by viral infection. This herbal extract granule for oral use, however, is not well accepted by infants or young children due to its unpleasant taste and odor. Therefore, we prepared Kampo medicine, maoto, suppository and investigated the pharmaceutical and clinical effi...

BACKGROUND AND OBJECTIVES A prospective, randomized study was designed to compare the maternal and neonatal effects of conventional epidural anesthesia and combined spinal epidural anesthesia (CSE) for Cesarean section in severe preeclamptic patients. Additionally, two strategies in the prophylactic management of hypotension in severe preeclamptic patients were evaluated: fluid preloading or pr...

Chloroephedrine is an intermediate and possible contaminant formed when methamphetamine is manufactured using ephedrine or pseudoephedrine as precursors. The purpose of this study was to determine whether this contaminant has biological activity and might contribute to methamphetamine-induced cardiovascular toxicity. In conscious rats, the (-) and (+) isomers of chloroephedrine (0.1 and 1.0 mg/...

Background Ephedrine was conventionally regarded as the first-choice drug to maintain maternal blood pressure during spinal anesthesia for cesarean delivery, due to its stimulant activity on α- and β-adrenergic receptors. Norepinephrine is a weak β-adrenergic and potent α-adrenergic receptor agonist. Therefore, it may be suitable for maintaining blood pressure with less chronotropic effects com...

During surgical procedures, patients can have potentially life-threatening hypotension that requires immediate treatment with ephedrine sulfate, which compounding at the patient’s bedside. This study was conducted to validate and compare Nexus Pharmaceutical’s EMERPHED®, a pre-diluted sulfate injection, commercially used concentrated in simulated clinical setting. Twenty-four simulations were p...

INTRODUCTION Hypotensive episodes are a common complication of spinal anesthesia during Cesarean section. The purpose of this study was to compare the effectiveness and the side effects of vasopressors, ephedrine and phenylephrine, administered for hypotension during elective Cesarean section under spinal anesthesia. MATERIAL AND METHODS The study consisted of 100 selected ASA I/II females sc...

This study was conducted to use the local Ephedra alata plant as a model for extracting and detecting alkaloids in stem of (alkaloids-rich extract crude extract). Different extraction procedures were adopted qualitative well quantitative examination alkaloid extracts, extract, best methods materials applied. Simple, fast accurate like TLC (thin layer chromatography) HPLC (High-performance liqui...

Background: Spinal anaesthesia is widely used for caesarean surgery because it provides a fast and profoundsensory motor block, on the other hand Hypotension very common complication of spinal anaesthesia.Hence Ephedrine infusion has to be control hypotension.Method: Out 60 (sixty), 30 were administrated with ephedrine controlled group was samequantity normal saline during anaesthesias. Hemodyn...