نتایج جستجو برای: ep4

تعداد نتایج: 999  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2001
A T Blikslager S M Pell K M Young

16,16-Dimethyl-PGE2 (PGE2) may interact with one of four prostaglandin type E (EP) receptors, which signal via cAMP (via EP2 or EP4 receptors) or intracellular Ca(2+) (via EP1 receptors). Furthermore, EP3 receptors have several splice variants, which may signal via cAMP or intracellular Ca(2+). We sought to determine the PGE2 receptor interactions that mediate recovery of transmucosal resistanc...

Journal: :Frontiers in bioscience : a journal and virtual library 2004
Takakazu Oka

Prostaglandin E2 (PGE2) is a principal fever mediator that induces hyperthermia when injected into the organum vasculosum lamina terminalis (OVLT) and the adjacent preoptic area of the hypothalamus (POA). PGE (EP) receptors have four subtypes, i.e. EP1, EP2, EP3, and EP4. In the rat OVLT/POA region, at least three of these receptors, i.e. EP1, EP3, and EP4 receptors, have distinctively differen...

Journal: :Journal of lipid research 2011
Tomoaki Inazumi Naritoshi Shirata Kazushi Morimoto Hirotsugu Takano Eri Segi-Nishida Yukihiko Sugimoto

The prostaglandin (PG) receptors EP4 and FP have the potential to exert negative effects on adipogenesis, but the exact contribution of endogenous PG-driven receptor signaling to this process is not fully understood. In this study, we employed an adipocyte differentiation system from mouse embryonic fibroblasts (MEF) and compared the effects of each PG receptor-deficiency on adipocyte different...

Journal: :Clinical chemistry 2004
Zeliang Chen Decui Pei Lingxiao Jiang Yajun Song Jin Wang Hongxia Wang Dongsheng Zhou Junhui Zhai Zongmin Du Bei Li Maofeng Qiu Yanping Han Zhaobiao Guo Ruifu Yang

BACKGROUND The widespread threat of severe acute respiratory syndrome (SARS) to human health has made urgent the development of fast and accurate analytical methods for its early diagnosis and a safe and efficient antiviral vaccine for preventive use. For this purpose, we investigated the antigenicity of different regions of the SARS coronavirus (SARS-CoV) nucleocapsid (N) protein. METHODS Th...

2000
Stefan Hosch Jürgen Kraus Peter Scheunemann Jakob Robert Izbicki Claus Schneider Udo Schumacher Klaus Witter Michael R. Speicher Klaus Pantel

Although micrometastatic cancer cells in lymph nodes can be detected by monoclonal antibodies against epithelial or tumor-associated antigens, it remains unclear whether these cells are precursors of overt metastases or shedded tumor cells with a limited life span. Here we used esophageal cancer as a model to evaluate the prognostic significance and biological characteristics of such micrometas...

Journal: :The Biochemical journal 2009
Gunther Zahner Melanie Schaper Ulf Panzer Malte Kluger Rolf A K Stahl Friedrich Thaiss André Schneider

The pro-inflammatory chemokine CCL2 [chemokine (Cys-Cys motif) ligand 2; also known as MCP-1 (monocyte chemotactic protein-1)] is up-regulated in the glomerular compartment during the early phase of LPS (lipopolysaccharide)-induced nephritis. This up-regulation also occurs in cultured MCs (mesangial cells) and is more pronounced in MCs lacking the PGE2 (prostaglandin E2) receptor EP2 or in MCs ...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
Laurent P Audoly Stephen L Tilley Jennifer Goulet Mikelle Key Mytrang Nguyen Jeffrey L Stock John D McNeish Beverly H Koller Thomas M Coffman

To identify the E-prostanoid (EP) receptors that mediate the hemodynamic actions of PGE2, we studied acute vascular responses to infusions of PGE2using lines of mice in which each of four EP receptors (EP1 through EP4) have been disrupted by gene targeting. In mixed groups of males and females, vasodepressor responses after infusions of PGE2were significantly diminished in the EP2 -/- and EP4 -...

Journal: :Cancer research 2009
Ying Zheng Jeffrey D Ritzenthaler XiaoJuan Sun Jesse Roman ShouWei Han

Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)) stimulates tumor cell growth and progression. However, the mechanisms by which PGE(2) increases tumor growth remain incompletely understood. In studies performed in non-small cell lung carcinoma (NSCLC) cells, we found that PGE(2) stimulates the expression of integrin-linked kinase (ILK). ILK small interfering RNA (siRNA) inhibited the mitoge...

Journal: :The Journal of Experimental Medicine 2008
Jernej Murn Olivier Alibert Ning Wu Simon Tendil Xavier Gidrol

B cell receptor (BCR) signaling contributes to the pathogenesis of B cell malignancies, and most B cell lymphomas depend on BCR signals for survival. Identification of genes that restrain BCR-mediated proliferation is therefore an important goal toward improving the therapy of B cell lymphoma. Here, we identify Ptger4 as a negative feedback regulator of proliferation in response to BCR signals ...

Journal: :Cancer research 2008
Shalini Jain Goutam Chakraborty Remya Raja Smita Kale Gopal C Kundu

In cancer management, the cyclooxygenase (COX)-targeted approach has shown great promise in anticancer therapeutics. However, the use of COX-2 inhibitors has side effects and health hazards; thus, targeting its major metabolite prostaglandin E(2) (PGE(2))-mediated signaling pathway might be a rational approach for the next generation of cancer management. Recent studies on several in vitro and ...

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