Heart failure (HF) is the cause of impaired exercise capacity due to insufficient peripheral blood flow. Development natriuretic peptide (NP) through inhibition neprilysin enzyme therapeutic target in HF. Treatment with sacubitril/valsartan has been shown significantly reduce mortality and hospitalization rehospitalization rates for HF compared enalapril. Sacubitril/valsartan may provide signif...

Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...