1Department of Industrial & Systems Engineering, The State University of New York (SUNY), Buffalo, NY 14260, USA 2Department of Computer Science Engineering, The State University of New York (SUNY), Buffalo, NY 14260, USA 3Department of Civil, Structural and Environmental Engineering, The State University of New York (SUNY), Buffalo, NY 14260, USA 4NYs Center for Engineering Design & Industrial...

The Dagstuhl working groups’ discussions provide many insightful perspectives and suggestions for defining a roadmap for Empirical Software Engineering (ESE) research. This summary attempts to consolidate these ideas into an overall roadmap. As emphasized in the roadmapping introduction, defining a roadmap is an ongoing process and the resulting roadmap needs to be considered a “living document...

UNLABELLED The aim of this study was to characterize the in vitro action of 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) on non-tumorigenic MCF-12A, tumorigenic MCF-7 and metastatic MDA-MB-231 breast cancer cells. ESE-16 is able to inhibit the activity of a carbonic anhydrase II and a mimic of carbonic anhydrase IX in the nanomolar range. Gene and protein expression studies using ...

Exonic splicing enhancer (ESE) sequences are bound by serine & arginine-rich (SR) proteins, which in turn enhance the recruitment of splicing factors. It was inferred from measurements of splicing around twenty years ago that Drosophila doublesex ESEs are bound stably by SR proteins, and that the bound proteins interact directly but with low probability with their targets. However, it has not b...

BACKGROUND In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously reported that a 70% ethanol extract of Elaeocarpus sylvestris leaves (ESE) inhibits human cytomegalovirus (HCMV) replication in vitro. In the present study, we determined the s...

Familial isolated GH deficiency type II (IGHD II) is caused, in some cases, by heterogeneous IVS3 mutations that affect GH mRNA splicing. We report here our finding an A-->G transition of the fifth base of exon 3 (E3+ 5 A-->G) in affected individuals from an IGHD II family. This mutation disrupts a (GAA)(n) exon splice enhancer (ESE) motif immediately following the weak IVS2 3' splice site. The...

E26 transformation-specific (Ets) family of transcription factors are characterized by the presence of Ets-DNA binding domain and have been found to be highly involved in hematopoiesis and various tissue differentiation. ESE-1, or Elf3 in mice, is a member of epithelium-specific Ets sub-family which is most prominently expressed in epithelial tissues such as the gut, mammary gland, and lung. Th...

Odor plume tracing is a challenging robotics application, made difficult by the combination of the patchy characteristics of odor distribution and the slow response of the available sensors. This work proposes a graph-based formation control algorithm to coordinate a group of small robots equipped with odor sensors, with the goal of tracing an odor plume to its source. This approach makes it po...

Megatrends wie Nachhaltigkeit, Digitalisierung und Globalisierung steigern die Komplexität in der Produktentstehung erfordern ein neues Paradigma: das Advanced Systems Engineering (ASE). Die Gestaltung nachhaltiger kreislaufwirtschaftlich optimierter Produkte Systeme ist eine zentrale Herausforderung, mit dem ASE adressiert werden kann. Der Beitrag beschreibt aktuelle Lösungsansätze aus Forschu...