The current treatment of haemophilia with coagulation protein replacement therapy is both effective and safe. Nevertheless, this therapy requires frequent, repeated intravenous infusions and approximately 25% of treated haemophilia A patients develop antibodies to the replacement protein. Furthermore, the cost and limited availability of current concentrates has restricted access to therapy to ...

Turbidity reaction of blood scrum has been developed. The turbidity is formed by serum albumin and comes about when the serum is diluted with MC!LWAINE phosphate-citrate buffer in the range of pH 3.9—4.4. It is significantly enhanced by warming the solution. The temperature must not exceed the point of coagulation. The reaction is suitable as a screening-test of pathological anomalies of serum ...

We report a case of 64-year-old male with prostate cancer and coagulation disorder presented with abdominal distension. He underwent abdomen and pelvis ultrasound for assessment of ascites, which showed localized fluid collections identified at the left and right iliac fossa. After that, non enhanced abdomen and pelvis CT scan was performed and showed heterogeneous organized collections identif...

Thrombophilic disorders encompass a diverse group of coagulation disorders that potentiate a predisposition for thrombotic events (e.g. deep vein thrombosis and pulmonary embolism). The term thrombophilia was coined in 1965 following a Norwegian familial study of venous thrombosis [1]. The entity of thrombophilia has also been described as a disorder in which there is abnormally, enhanced coagu...

The occurrence of peritoneal adhesions in surgical patients is positively correlated with tumor necrosis factor (TNF) levels. In a model of septic peritonitis-cecal ligation and puncture-TNF neutralization prevented formation of peritoneal adhesions and increased mortality, most likely because localization of the septic focus was prevented. To discriminate between the coagulation-independent pr...

background recombinant activated factor vii (rfviia; novoseven® rt, novo nordisk, bagsvaerd, denmark) is a synthetic pro-coagulation factor derived from hamster kidney cells. objectives the purpose of this study was to evaluate the prescribing patterns of recombinant factor viia (rfviia) at a single, tertiary care pediatric hospital by indication of usage and dose administered. materials and me...

conclusions to solve the above mentioned difficulties, fundamental study most be carried out to discover the novel methods of ferrate(vi) production, focusing on increasing the product stability and the production yield. results despite the existence of these technologies, there is no full-scale application of ferrate(vi) in the water and wastewater industry which it is due to difficulties asso...

BACKGROUND Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activity in colon cancer patients. METHODS PS-positive platelets and MPs, mainly...

An in vitro aggregation of washed lutoid membrane and rubber particles, respectively, prepared from the bottom (lutoid) fraction and rubber layer of centrifuged fresh latex, leading to the formation of rubber coagulum necessary for a latex coagulation was demonstrated. A Triton X-100 extract of washed lutoid membrane proteins, isolated and prepared from the bottom fraction of centrifuged fresh ...