Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial malignancies at other sites, including the female reproductive tract. Here we show that female mice heterozygous for a null Lkb1 allele spontaneously develop highly in...

STUDY QUESTION What is the role of the inhibitor of apoptosis proteins (IAPs) in human endometriotic tissues and a mouse model of endometriosis? SUMMARY ANSWER Four IAP proteins were expressed in endometriotic tissue indicating IAPs may be a key factor in the pathogenesis and progression of endometriosis. WHAT IS KNOWN ALREADY Overexpression of IAPs protects against a number of proapoptotic...

BACKGROUND The objective of this study was to compare the classical method and Sectioning and Extensively Examining the Fimbriated End Protocol (SEE-FIM) in detecting microscopic lesions in fallopian tubes with gynecological lesions. METHODS From a total of 1,118 cases, 582 with various parts of both fallopian tubes sampled in three-ring-shape sections and 536 sampled with the SEE-FIM protoco...

Diffuse uterine enlargement is a common clinical finding. Because this abnormality can represent a physiologic manifestation, benign tumor, or malignancy, the diagnostic dilemma of a diffusely enlarged uterus can be challenging. Clinical findings can provide valuable information in regard to physiologic effects, pregnancy-related changes, and hormonal causes. Cytologic examination is essential ...

Background: Endometrial stroma sarcoma (ESS) is usually formed of neoplastic cells similar to proliferative endometrial cells and comprises less than 10% of all uterine sarcomas. Presence of concurrent sex cord element with these tumors is rare. Materials and Methods: A 36 year-old woman,from yazd complaining of abnormal vaginal bleeding and history of G4P3Ab1Ch3 referred. On both occasions aft...

abstract background: abnormal uterine bleeding (aub) is one of the most common complains in women of any age seeking gynecologic health care and needs early diagnosis and proper management due to its impacts on the quality of life. this study was conducted to investigate the cut-off value of endometrial thickness (et) by trans-vaginal ultra-sonography (tvus) and evaluate its accuracy in the dia...

Background: Xanthogranulomatous inflammation of the female reproductive organs is a rare chronic inflammation. In most reported cases, lesion was limited to endometrium and fallopian tubes. Here, we report two cases xanthogranulomatous myometrium with history endometrial biopsy. Case Reports: myometrial destroyed myometrium. This developed into surrounding pelvic organs, resulting in uterine pe...

BACKGROUND Endometriosis is a relatively common disease among women with child-bearing potential, and rare before puberty or following menopause. It consists of the presence of hormone-responsive endometrium outside the endometrial cavity. CASE REPORT We report the case of a patient with a rectal lesion, initially approached as a primary rectal malignancy, where histopathology eventually reve...

Background Endometriosis is a gynecological disease defined as the presence of endometrial tissue outside the uterine cavity, which caused by various factors. Recent evidences support the presence of endometrial stem cells and their possible involvement in endometriosis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play a role in the etiology of endometri...

pulmonary embolism 17 months after the diagnosis of brain metastases. Metastases confined to the thalami have seldom been reported [1] , and bilateral localization of endometrial adenocarcinoma is exceptional. A 61-year-old woman presented with dysesthesia of the face and upper limbs, memory impairment and apathy. T 1 -weighted MRI showed mass lesions in both thalami ( fig. 1 ). Her medical his...