POEMS syndrome, also called Osteosclerotic myeloma or Takatsuki syndrome Crow-Fukase is a rare multisystemic disease paraneoplastic under the plasma cell dyscrasias. an acronym for Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein elevation, and skin changes. It usually 1.5 times more common in male than female. Patients often present fifth to sixth decades of life have median su...

Castleman’s disease (CD), also known as Angiofollicular lymph node hyperplasia, is a rare lymphoproliferative disorder first reported by dr. Benjamin Castleman in 1956. The estimated incidence rate 5 to 25 per million person-years. Histologically, the CD can be classified hyaline-vascular type, plasma cell type and mixed type. HHV-8-associated MCD (Multicentric CD) most commonly diagnosed HIV-i...

Lymphocytic hypophysitis (LH) is a new clinico pathological entity, first described in 1962 by Goudie [46]. With recent advances in radiological investigation and technical refinements of trans-sphenoidal surgery, LH cases are being reported with increasing frequency. A total of 145 cases have been reported to date, 102 of them since 1990, with 121 histologically proven. LH is an autoimmune end...

BACKGROUND The choice of endoscopic expanded endonasal approach introduces the possibility of improved gross total resection of craniopharyngioma while minimizing surgical morbidity in a significant subset of patients. METHODS From our trans-sphenoidal surgical series of 331 cases, we retrospectively reviewed visual, endocrine and neuro-cognitive outcomes in the first consecutive eight patien...

Dolores Albarracín and Wei Wang Department of Psychology University of Florida History presents abundant examples that people who strongly advocate and defend a given attitudinal position often change this position, becoming “converted” to points of view that are opposite to the ones they initially held. One reason for such changes is the degree to which individuals perceive that they can defen...

BACKGROUND Endocrinologic abnormalities are a common co-morbidity in patients with optic nerve hypoplasia (ONH), however the impact on puberty is unknown. The purpose of this study was to examine rates of endocrine dysfunction and pubertal disturbances in a pediatric population of ONH. METHODS A retrospective chart review was conducted on a cohort of children with ONH between January 2005 and...

This case suggests that POEMS syndrome does present with a constellation of signs and symptoms may lead clinician to multitude other possible diagnoses. Diagnosis is often difficult delayed. A good history physical examination as well careful review all workups are paramount in establishing this particular diagnosis. The major criteria diagnostic for the polyradiculoneuropathy, clonal plasma di...