Human serum albumin nanoparticles (HSA-NPs) are widely-used drug delivery systems with applications in various diseases, like cancer. For intravenous administration of HSA-NPs, the particle size, surface charge, drug loading and in vitro release kinetics are important parameters for consideration. This study focuses on the development of stable HSA-NPs containing the anti-cancer drug paclitaxel...

Diabetic foot ulcers (DFUs) represent a major clinical challenge in the ageing population. To address this problem, rhEGF-loaded Poly-Lactic-co-Glycolic-Acid (PLGA)-Alginate microspheres (MS) were prepared by a modified w/o/w-double-emulsion/solvent evaporation method. Different formulations were evaluated with the aim of optimising MSs properties by adding NaCl to the surfactant solution and/o...

To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide-co-glycolide) nanoparticles (NPs) were formulated by single emulsion-solvent evaporation method by changing different formulation parameters such as drug loading, choice of organic solvent and percentage of emulsifier polyvinyl alcohol. The NPs showed higher entrapment efficiency, ~86% (with 15% (w/...

Controlled release systems can modify the rate of drugs and direct them to specific sites action, making more effective and/or reducing adverse effects. The objective this study was investigated, poly(β-hydroxybutyrate) (PHB) poly(ε-caprolactone) (PCL) nanospheres improve delivery Simvastatin (SIM). Nanospheres were prepared by emulsion/evaporation technique solvent, varying amount SIM added. q...

Metformin hydrochloride (MET) sustained-release solid dispersions (SD) were prepared by the solvent evaporation and closed melt method, using compritol 888 ATO as the polymer with five different drug-carrier ratios. Characterization of solid dispersion was carried out by Fourier Transform Infrared (FTIR) spectroscopy, ultraviolet (UV) spectroscopy, Differential scanning calorimetry (DSC), X-ray...

Nanoparticular systems, which have made great advances with the development of nanotechnology, been used extensively recently in pesticide, herbicide plant growth regulators, fertilizer applications, gene transfer technologies and agriculture. It was aimed to synthesize characterize 2,4-D loaded PLGA nanoparticles investigate their biological activity comparison its free form. Here, effects pol...

The present work reports on the synthesis of cellulose acetate (CA) asymmetric membranes with the incorporation of inorganic fluorides, CaF2 particles. These fillers of polymeric composites can, according to the literature, promote the ordering of the polymer matrix, which can lead to interesting permeation properties. In order to achieve that, fluorite (CaF2 ) fine particles were prepared by a...

Purpose: To prepare and evaluate spherical agglomerates of pioglitazone hydrochloride (PGH) for direct compression with different additives. Method: Spherical agglomerates of pioglitazone hydrochloride were prepared by emulsion solvent diffusion method with and without additives (polyethylene glycol 6000, polyvinyl pyrrolidone, β cyclodextrin, Eudragit RS100, low acyl gellan gum and xanthan gum...

Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using PEG 6000 as carrier at various proportions by using different techniques like Physical mi...