The present study was aimed to develop and optimize the microsponges of curcumin for colon specific drug delivery in a view to bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method using 3(2) full factorial design. Prepared microsponges were optimized in order to analyze the effects of independent va...

PURPOSE Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles (NPs) using PLGA polymer and to compare the effectiveness of prepared nanoparticles with untreated AZI solution. METHODS AZI NPs were prepared by Modified Quasi-Emulsion Solve...

The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo. Paeonol microsponges were prepared using the quasi-emulsion solvent-diffusion method. In vitro release studies were carried out using Franz diffusion cells, while in vivo studies were investi...

A study of the diffusion of parabens from topical formulations is presented here. In particular, four different topical formulations, namely, a water-in-oil emulsion, an oil-in-water emulsion, and two hydrophilic gels (Pemulen gel and Carbopol gel) were produced, containing a mixture of three common parabens, namely, methylparaben (MP), ethylparaben (EP), and propylparaben (PP). An analytical m...

*To whom all correspondence should be addressed. he quality of a solid pharmaceutical preparation is influenced by primary micromeritic characteristics such as the shape and size of drug crystals, especially when large amounts of poorly soluble drugs are formulated. To improve the dissolution rate of poorly soluble drugs, fine crystals are preferred over large crystals because they provide a gr...

The condition of oligo-micelle formation of sodium di-isodecyl sulfosuccinate (SDIDS) emulsifier in hydroalcoholic solutions is used to study particle formation of vinyl chloride emulsion polymerization in a batch reactor. The change on micellization behavior was investigated by critical micelle concentration (CMC) and zeta potential parameters. To detect the occurrence of secondary nucleation ...

The aim of this study was to evaluate microencapsulated controlled release preparations of tolmetin sodium using ethylcellulose as a retardant material. Microspheres were prepared by using water-in-oil-in-oil (W/O(1)/O(2)) double-emulsion solvent diffusion method, using different ratios of ethylcellulose to tolmetin sodium. Span 80 was used as the droplet stabilizer and n-hexane was added to ha...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

We have systematically investigated the diffusion behavior of silica nanoparticles within supercritical ethanol, in terms of solvent properties by varying temperature (T) and pressure (P), to elucidate how the inhomogeneous solvent structures and density fluctuations in the solvent affect the diffusion behavior of solute particles. Results show that at a constant pressure, the diffusion coeffic...

Alginate based mineral oil entrapped emulsion gel (MOEG) buoyant beads of domperidone were prepared by emulsion gelation technique. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content and entrapment efficiency. Effect of different oils (castor oil, olive oil and linseed oil) and oil concentrations (10%, 15% and 20%, w/w) on uniformity, homogene...