in worldwide, an estimated 40 cases per 1 million people reported with new spinal cord injuries each year. people with spinal cord injuries suffer from severe physical, psychological, social and economic problems. damaged or lost cells can't be replaced when the spinal cord is injured; therefore, its function becomes disturbed permanently. despite the significant advances in the understand...

Teratomas are bulky lesions that rarely occur in the head and neck regions.They are composed of tissues from all germ layers with varying degrees of differentiation. They arise from pluripotential stem cells and ectopic embryonic non-germ cells. The most common sites of occurrence in the head and neck are the cervical region and the nasopharynx. Three cases of these tumors are reported here...

Introduction:First, definition the stem cell refers to those cells that are still not clear and are not equipped for a particular task. These cells have proliferative properties and  ability to differentiate into other types of cells have become. This characteristic of stem cells to self-directed has absorbed professional opinion that extensive research is done in this regard. Nowadays, stem ce...

Two new briarane diterpenoids briareolate esters J (1) and K (2) were isolated from the methanolic extract of the octocoral Briareum asbestinum collected off the coast of Boca Raton, Florida. The structures of briaranes 1 and 2 were elucidated by interpretation of spectroscopic data. Briareolate ester K (2) showed weak growth inhibition activity against human embryonic stem cells (BG02).

Stem cells hold promise to treat diseases currently unapproachable, including Parkinson's disease, liver disease and diabetes. Seminal research has demonstrated the ability of embryonic and adult stem cells to differentiate into clinically useful cell types in vitro and in vivo. More recently, the potential of fetal stem cells derived from extra-embryonic tissues has been investigated. Fetal st...

Somatic cell nuclear transfer and transcription factor mediated reprogramming are two widely used techniques for somatic cell reprogramming. Both fully reprogrammed nuclear transfer embryonic stem cells and induced pluripotent stem cells hold potential for regenerative medicine, and evaluation of the stem cell pluripotency state is crucial for these applications. Previous reports have shown tha...

personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. this approach has established based on pharmacogenetic and pharmacogenomic information and data. the terms precision and personalized medicines are sometimes applied interchangeably. however, there has been a shift from “personalized medicine” towards “precision me...

There are a sub-population of cells in tumor tissues known as cancer stem cells (CSCs) which have similar features with stem cells, including self-renewal and differentiation capacity. Recently, it was established that not only stem cells factors such as Oct4, but also ES-associated lncRNAs are contributing to various regulatory aspects of CSCs. Myocardial infarction associated transcript (MIAT...

Background This research studies the effects of activation and inhibition of Wnt3A signaling pathway in buffalo (Bubalus bubalis) embryonic stem (ES) cell-like cells. MaterialsAndMethods To carry on this experimental study, the effects of activation and inhibition of Wnt3A signaling in buffalo ES cell-like cells were examined using Bio (0.5 mM) combined with WNT3A (200 ng/ml), as an activator, ...