Appendiceal neoplasms include a heterogeneous group of epithelial and nonepithelial tumors that exhibit varying malignant potential. This review article summarizes current diagnostic criteria, classification systems, optimal therapeutic strategies for the five main histopathologic subtypes appendiceal neoplasms. In particular, management has evolved. Although their treatment historically been e...

Gestational trophoblastic neoplasms are a group of fetal trophoblastic tumors including choriocarcinomas, epithelioid trophoblastic tumors (ETTs), and placental site trophoblastic tumors (PSTTs). Mixed gestational trophoblastic neoplasms are extremely rare. The existence of mixed gestational trophoblastic neoplasms that were composed of choriocarcinoma and/or PSTT and/or ETT was also reported. ...

True histiocytic lymphomas (THLs) are rare tumors in which the malignant cells show morphologic and immunophenotypic evidence of histiocytic differentiation. We describe THLs that arose after therapy for one case of T-lineage lymphoblastic lymphoma (LyL) and two cases of acute lymphoblastic leukemia (ALL) (both CD10+, one pre-B phenotype). The lymphoblastic neoplasms were not unusual in any way...

Of 291 juvenile and adult snakes examined post mortem over a 20-year period (1978-1997) at the National Zoological Park (NZP) in Washington, DC, 36 (24 females and 12 males) had neoplasms. Two snakes had tumours of two or three different types, but the other 34 snakes had only one type. All affected animals were adults and their average time on exhibit at the NZP was 108-9 months. Malignant neo...

Conventional radiography continues to be the most important imaging modality in the initial diagnosis and assessment of skeletal neoplasms. However, this technique is usually inadequate to determine the local extent of the tumor, particularly in malignancies. Angiography also fails to define accurately the local extent of most skeletal neoplasms. Computed tomography, however, demonstrates the i...

The transcription factor LMO2 is involved in vascular and hematopoietic development and hematolymphoid neoplasia. We have demonstrated that LMO2 is expressed nearly ubiquitously in native and neoplastic vasculature, including lymphatics. LMO2 reactivity is otherwise virtually absent in nonhematolymphoid tissues except in breast myoepithelium, prostatic basal cells, and secretory phase endometri...

We investigated the organization of the immunoglobulin heavy chain (IgH) and the T cell receptor beta chain (T$) gene loci in 20 ocular adnexal and four extraocular lymphoid neoplasms obtained from 1 8 patients presenting with an ocular adnexal lymphoid neoplasm. Fifteen ocular adnexal and four extraocular lymphoid neoplasms occurring in 1 3 patients were classified by morphological examination...

Philadelphia-chromosome negative chronic myeloproliferative neoplasms are clonal hematologic diseases characterized by hematopoietic progenitor independence from or hypersensitivity to cytokines. The cellular and molecular mechanisms involved in the pathophysiology of myeloproliferative neoplasms have not yet been fully clarified. Pathophysiologic findings relevant for myeloproliferative neopla...

Out of all the different types of neoplasms affecting the stomach, gastric carcinomas with Osteoclast-like Giant Cells (OGC) is one of the most uncommon. Although OGC are typically found in osseous neoplasms and tumors of the tendon sheath, few cases of extra-skeletal neoplasms with OGC have been documented. These typically involve organs such as the pancreas, gall-bladder, kidney, and breast. ...