Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods: Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95%...

Aims: This study is to systematically investigate the relationship between metformin and risk of pancreatic cancer in patients with type 2 diabetes mellitus. Methods: A systematic literature search was performed on PubMed, Embase, Cochrane Library, Highwire, CBM, CNKI, Wanfang, VIP databases. Cohort or case control studies of metformin and risk of pancreatic cancer in patients with type 2 diabe...

Introduction: Informing children of their own HIV status is an important aspect of long-term disease management, yet there is little evidence of how and when this type of disclosure takes place in resource-limited settings and its impact. Methods: MEDLINE, EMBASE and Cochrane Databases were searched for the terms hiv AND disclos* AND (child* OR adolesc*). We reviewed 934 article citations and t...

Objective: To investigate the effects of known potential sources of bias on whether acupuncture is beneficial in treating stroke. Data sources: Cochrane Library, MEDLINE, EMBASE, PubMed and reference lists of previous reviews were used to seek randomised controlled trials. There were seven randomised trials that met the inclusion criteria. Methods: Pooling of outcomes was known to be unlikely. ...

Objective: The aim of this study was to indirectly compare the efficacy and safety of anti-tumor necrosis factor α (TNFα) agents and an interleukin (IL)-17A inhibitor Secukinmuab for the treatment of ankylosing spondylitis (AS). Methods: Literatures were searched in Pubmed, Medline, Embase and the Cochrane library to screen citations from January 1996 to December 2015. The mixed treatment compa...

Background: Reviews of the epidemiology of Huntington’s disease (HD) suggest that its worldwide prevalence varies widely. This review was undertaken to confirm these observations, to assess the extent to which differences in caseascertainment and/or diagnosis might be responsible, and to investigate whether the prevalence pattern has changed over the past 50 years. Methods: Eighty two relevant ...

Background: Horseback riding is more dangerous than motorcycle riding, skiing, football, and rugby. The purpose of this study was to identify the incidence and injury patterns, as well as risk factors associated with severe equestrian trauma. Methods: All patients with major equestrian injuries (injury severity score 12) admitted between 1995 and 2005 were reviewed. A 46-question survey outlini...

Some studies suggested that prediabetes was associated with the risk of pancreatic cancer. However, the results were controversial. Thus, a meta-analysis was conducted to investigate the association between prediabetes and pancreatic cancer risk. PubMed, EMBASE, and Cochrane database were searched. The association was estimated by hazard ratio (HR) with its 95% confidence interval (CI). 12 stud...

Article history: Received on: 16/02/2015 Revised on: 03/04/2015 Accepted on: 17/06/2015 Available online: 28/08/2015 The use of opioids has gain popularity in the field of medicine especially in treating chronic terminally ill patients. Unfortunately, several adverse effects in relation to its use have been reported. Literature search on the adversity of opioids in treating pain, its paradoxica...

Introduction: Retrograde transfemoral and antegrade transapical approaches are mostly used for transcatheter aortic valve replacement. This meta-analysis is designed to assess the performance of the transfemoral and transapical approach. Methods: A systematic search was conducted using MEDLINE, PubMed, EMBASE, Current