نتایج جستجو برای: efflux pump

تعداد نتایج: 78705  

Journal: :Antimicrobial Agents and Chemotherapy 1993

Journal: :Biological and Pharmaceutical Bulletin 2006

Journal: :Journal of the Brazilian Chemical Society 2016

2007
John B. Bremner

Bacteria use a number of resistance mechanisms to counter the antibacterial challenge, and one of these is the expression of transmembrane protein-based efflux pumps which can pump out antibacterials from within the cells, thus lowering the antibacterial concentration to nonlethal levels. For example, in S. aureus, the NorA pump can pump out the antibacterial alkaloid berberine and ciprofloxaci...

2011
Rithika Kulathila Ragini Kulathila Mridhu Indic Bert van den Berg

BACKGROUND While copper has essential functions as an enzymatic co-factor, excess copper ions are toxic for cells, necessitating mechanisms for regulating its levels. The cusCBFA operon of E. coli encodes a four-component efflux pump dedicated to the extrusion of Cu(I) and Ag(I) ions. METHODOLOGY/PRINCIPAL FINDINGS We have solved the X-ray crystal structure of CusC, the outer membrane compone...

2014
Marie Blanchette Suzanne Gascon Sébastien Tremblay Luc Tremblay Brigitte Guérin Martin Lepage Roger Lecomte

ET-07. DOES OSMOTIC BLOOD-BRAIN BARRIER DISRUPTION ALLOWS EFFLUX PUMP SUBSTRATES DELIVERY TO THE

Journal: :Microbes and Infectious Diseases (Print) 2021

Background: Meropenem resistance of Pseudomonas aeruginosa (P. aeruginosa) is considered an increasing problem. Efflux pump one multiple mechanisms that are responsible for this resistance. This study aimed to phenotypically and genotypically detect prevalence efflux mediated meropenem among P. isolates. Methods: Pseudomonas was isolated from different clinical specimens identified by conventio...

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