نتایج جستجو برای: ed50

تعداد نتایج: 1587  

Journal: :Journal of biomedical optics 2015
Jenny Wang Jae Lim Chung Georg Schuele Alexander Vankov Roopa Dalal Michael Wiltberger Daniel Palanker

A recent study showed that 355-nm nanosecond lasers cut cornea with similar precision to infrared femtosecond lasers. However, use of ultraviolet wavelength requires precise assessment of ocular safety to determine the range of possible ophthalmic applications. In this study, the 355-nm nanosecond laser was evaluated for corneal and iris damage in rabbit, porcine, and human donor eyes as determ...

2015
Xiaoyu Hu Fang Huang Magdalena Szymusiak Ying Liu Zaijie Jim Wang John E. Baker Jidong Su Stacy Koprowski Anuradha Dhanasekaran Tom P. Aufderheide Garrett J. Gross Christian A. Fernandez Colton Smith Seth E. Karol Laura B. Ramsey Chengcheng Liu Ching-Hon Pui Sima Jeha William E. Evans Fred D. Finkelman Mary V. Relling Ana Cristina G. Grodzki Bhaskar Poola Nagarekha Pasupuleti Michael H. Nantz Pamela J. Lein Fredric Gorin Taryn E. Dick Jeremy A. Hengst Todd E. Fox Ashley L. Colledge Vijay P. Kale Shen-Shu Sung Arun Sharma Shantu Amin Thomas P. Loughran Mark Kester Hong-Gang Wang Jong K. Yun Nadia Moretto Paola Caruso Raffaella Bosco Gessica Marchini Fiorella Pastore Elisabetta Armani Gabriele Amari Andrea Rizzi Eleonora Ghidini Renato De Fanti Carmelida Capaldi Laura Carzaniga Emilio Hirsch Carola Buccellati Angelo Sala Chiara Carnini Riccardo Patacchini Maurizio Delcanale Maurizio Civelli Gino Villetti Fabrizio Facchinetti Dorothea Rudolph Maria Antonietta Impagnatiello Claudia Blaukopf Christoph Sommer Daniel W. Gerlich Mareike Roth Ulrike Tontsch-Grunt Andreas Wernitznig Fabio Savarese Marco H. Hofmann Christoph Albrecht Lena Geiselmann Markus Reschke Pilar Garin-Chesa Johannes Zuber Jürgen Moll Günther R. Adolf Pascal Bonaventure Sujin Yun Philip L. Johnson Anantha Shekhar Stephanie D. Fitz Brock T. Shireman Terry P. Lebold Diane Nepomuceno Brian Lord Michelle Wennerholm Jonathan Shelton Christine Dugovic Peter V. Dicpinigaitis Brendan J. Canning Rachel Garner Seong-Joon Koh Ji Won Kim Byeong Gwan Kim Kook Lae Lee Jaeyoung Chun Joo Sung Kim

Chronic use of opioid analgesics has been hindered by the development of opioid addiction and tolerance. We have reported that curcumin, a natural flavonoid from the rhizome of Curcuma longa, attenuated opioid tolerance, although the underlying mechanism remains unclear. In this study, we tested the hypothesis that curcumin may inhibit Ca/calmodulin-dependent protein kinase II a (CaMKIIa), a pr...

2015
Roger H Brookes Marin Ming Kimberley Williams Robert Hopfer Sanjay Gurunathan Scott Gallichan Mei Tang Martina M Ochs

Currently marketed Streptococcus pneumoniae vaccines are based on polysaccharide capsular antigens from the most common strains. Pneumococcal histidine triad protein D (PhtD) is a conserved surface protein that is being evaluated as a candidate for a vaccine with improved serotype coverage. Here, we measured the functional activity of human anti-PhtD antibodies in a passive protection model whe...

Journal: :Anesthesia and analgesia 2007
Josée Guindon Jesse LoVerme Daniele Piomelli Pierre Beaulieu

BACKGROUND Propofol can inhibit fatty acid amidohydrolase, the enzyme responsible for the metabolism of anandamide (an endocannabinoid). To study the potential antinociceptive effect of propofol, we administered different doses (0.005, 0.05, 0.5, 5, and 500 microg) of the anesthetic in the hind paw of animals to determine an ED50. To further investigate the mechanisms by which propofol produced...

Journal: :حفاظت گیاهان 0
سید احمد حسینی محمد حسن راشد محصل ابراهیم کازرونی کمال حاج محمدنیا قالی باف

in order to study the tolerance level of different wild barley (hordeum spontaneum) populations to clodinafop propargyl (topic®), a pot dose response experiment was conducted in a completely randomized design with three replications at ferdowsi university of mashhad greenhouse in 2009. cultivared barley (hordeum vulgare) and three wild barley populations (shiraz, boshroyeh, and torogh) were stu...

Journal: :Canadian journal of anaesthesia = Journal canadien d'anesthesie 1996
S Inomata T Nishikawa

PURPOSE Using the conventional method of determining the end-tidal concentration of inhalational anaesthetic for tracheal intubation, a constant end-tidal anaesthetic concentration is maintained for at least 15 min. As sevoflurane has a low tissue/gas partition coefficient, it seems possible in paediatric patients to determine end-tidal concentrations for tracheal intubation more rapidly by usi...

Journal: :Journal of cardiovascular electrophysiology 2002
James P Keener

INTRODUCTION Recent defibrillation studies show that electric fields interact with reentrant activity in myocardial tissue through virtual electrode polarization (VEP). This study focuses on determining how VEP relates to the creation and survival of postshock phase singularities in cardiac tissue and demonstrating that interactions between VEP and preshock tissue state engender the probabilist...

Journal: :Hypertension 1981
I Saito E L Bravo T Zanella S Sen F M Bumpus

The steroidogenic properties of a glycoprotein fraction (urinary ASF), isolated from normal human urine, were studied in collagenase-dispersed rabbit adrenal capsular cells in 1) define the requirements for its steroidogenic activity, and 2) assess its site and mode of action. When incubated with adrenal cell suspension at 37 degrees C for 2 hours, urinary ASF induced dose-related increases in ...

2013
Yuh-Shuen Chen Hua-Chian Liou Chin-Feng Chan

This is the first study to investigate the biological activities of fermented extracts of Rhodiola rosea L. (Crassulaceae) and Lonicera japonica Thunb. (Caprifoliaceae). Alcaligenes piechaudii CC-ESB2 fermented and ethanol extracts of Rhodiola rosea and Lonicera japonica were prepared and the antioxidative activities of different concentrations of samples were evaluated using in vitro antioxida...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Michael F Jarvis Edward C Burgard Steve McGaraughty Prisca Honore Kevin Lynch Timothy J Brennan Alberto Subieta Tim Van Biesen Jayne Cartmell Bruce Bianchi Wende Niforatos Karen Kage Haixia Yu Joe Mikusa Carol T Wismer Chang Z Zhu Katharine Chu Chih-Hung Lee Andrew O Stewart James Polakowski Bryan F Cox Elizabeth Kowaluk Michael Williams James Sullivan Connie Faltynek

P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocked recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22-92 nM) an...

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