Kalogeris, Theodore J., F. Stephen Laroux, Adam Cockrell, Hiroshi Ichikawa, Naotsuka Okayama, Travis J. Phifer, J. StevenAlexander, and Matthew B. Grisham. Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells. Am. J. Physiol. 276 (Cell Physiol. 45): C856–C864, 1999.—The objective of this study was to assess the effects of two structura...

BACKGROUND Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in the presence of myocardial fibrosis. The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region. METHODS 31 study subjects were enrolled and underwent one car...

Background: Prenatal exposures to stress and physical toxins influence children’s respiratory health, although few studies consider these factors together. Objectives: We sought to concurrently examine the effects of prenatal community-level psychosocial (exposure to community violence [ECV]) and physical (air pollution) stressors on repeated wheeze in 708 urban children followed to age 2 years...

Background—Extracellular matrix expansion may be a fundamental feature of adverse myocardial remodeling, it appears to be treatable, and its measurement may improve risk stratification. Yet, the relationship between mortality and extracellular matrix is not clear because of difficulties with its measurement. To assess its relationship with outcomes, we used novel, validated cardiovascular magne...

BACKGROUND Extracellular matrix expansion may be a fundamental feature of adverse myocardial remodeling, it appears to be treatable, and its measurement may improve risk stratification. Yet, the relationship between mortality and extracellular matrix is not clear because of difficulties with its measurement. To assess its relationship with outcomes, we used novel, validated cardiovascular magne...

We have read with great interest the recent report regarding increased cardiac extracellular volume (ECV) and impaired left ventricular (LV) mechanics in hypertensive patients (1). The study was innovative, and it may provide answers to many questions about left ventricular hypertrophy (LVH) and LV mechanics in hypertension. There are several important topics that deserve comment. The investiga...

We have previously characterized the receptor for glucose-dependent insulinotropic polypeptide (GIPR) in vascular endothelial cells (EC). Different EC types were found to contain distinct GIPR splice variants. To determine whether activation of the GIPR splice variants resulted in different cellular responses, we examined GIP effects on human umbilical vein endothelial cells (HUVEC), which cont...

AIMS We sought predictors of successful electrical cardioversion (ECV) and the effect of biphasic energy in patients considered candidates for rhythm control. METHODS AND RESULTS The patients were drawn from a registry, which included prospectively 1355 consecutive patients with persistent atrial fibrillation who underwent ECV in 96 Spanish hospitals. Successful ECV was considered excluding p...