Purpose: In this study, cytotoxicity and whitening effects of liposomes non-liposomes containing Geranium maculatum (G. maculatum) were measured to confirm their functionality as a cosmetic material.Methods: The test was used measure the effect G. in on B16F10 cells, performed inhibitory melanin tyrosinase production. Furthermore, LPS-induced NO production determined RAW 264.7 cells. Cell viabi...

This investigation determined the organ distribution of liposomes containing egg phosphatidylcholine and cholesterol with egg phosphatidylglycerol (PG liposomes) or without (PC liposomes) and the effect of each liposome on platelet distribution in rabbits. Eight minutes after 51chromium-labelled platelets were given intravenously, either saline (n = 7), iodinated PG liposomes (n = 5) or iodinat...

In this study, long-circulating Arg-Gly-Asp (RGD)-modified aclacinomycin A (ACM) liposomes were prepared by thin film hydration method. Their morphology, particle size, encapsulation efficiency, and in vitro release were investigated. The RGD-ACM liposomes was about 160 nm in size and had the visual appearance of a yellowish suspension. The zeta potential was -22.2 mV and the encapsulation effi...

Liposomes (lipid vesicles) are often considered to be a versatile tool for the synthesis of advanced materials, as they allow various control mechanisms tune materials’ properties. Among diverse calcium phosphates (CaPs) and carbonates (CaCO3) using liposomes has attracted particular attention in development novel (bio)materials biomineralization research. However, preparation materials not yet...

Liposomes are nanocarriers consisting of a phospholipid bilayer, similar in composition and structure to cell membrane. Such feature provides several possibilities related the transport delivery biologically active substances specific cells organisms. It is now becoming more popular modify lipid carrier shells achieve higher specificity efficiency into cells, reduce immunogenicity. The article ...

Functional and ultrastructural studies of liposomes injected i.v. into inbred C57BL/6N mice were performed to determine whether free liposomes can traverse capillaries. In the liver and spleen, organs with discontinuous (sinusoidal) capillaries, ultrastructural and cell fractionation studies revealed that small (300to 800-Â diameter), sonicated, unilamellar liposomes were more efficient in pen...

BACKGROUND/AIMS In designing a versatile liposomal drug carrier to hepatic stellate cells (HSC), the interaction of mannose 6-phosphate human serum albumin (M6P-HSA) liposomes with cultured cells was studied. METHODS M6P-HSA was covalently coupled to the liposomal surface and the uptake and binding of 3H-labelled M6P-HSA liposomes by primary rat HSC and liver endothelial cells was determined....

BACKGROUND The aim of this study was to investigate the intestinal mucus-penetrating properties and intestinal cellular uptake of two types of liposomes modified by Pluronic F127 (PF127). METHODS The two types of liposomes, ie, PF127-inlaid liposomes and PF127-adsorbed liposomes, were prepared by a thin-film hydration method followed by extrusion, in which coumarin 6 was loaded as a fluoresce...

The traditional mode of encapsulating drugs in liposomes poses risks to drug stability, especially when recognition agents are attached to the liposomal surface to obtain targeted liposomes. To reduce such risks, we devised a simple, novel method to entrap drugs in liposomes, consisting of (i) preparation and lyophilization of drug-free regular and surface-modified liposomes and (ii) drug encap...

Liposomes are widely investigated as vaccine delivery systems, but antigen loading efficiency can be low. Moreover, adsorbed may rapidly desorb under physiological conditions. Encapsulation of antigens overcomes the latter problem results in significant loss during preparation and purification liposomes. Here, we propose an alternative attachment method, based on a complementary heterodimeric c...