نتایج جستجو برای: ebolavirus
تعداد نتایج: 1058 فیلتر نتایج به سال:
Gammaretroviruses, such as murine leukemia viruses (MLVs), encode, in addition to the canonical Gag, Pol, and Env proteins that will form progeny virus particles, a protein called "glycogag" (glycosylated Gag). MLV glycogag contains the entire Gag sequence plus an 88-residue N-terminal extension. It has recently been reported that glycogag, like the Nef protein of HIV-1, counteracts the antivir...
Since the current International Health Regulations were implemented in 2007, the World Health Organization has declared only three events to be public health emergencies of international concern: the 2009 H1N1 infl uenza pandemic, the recent resurgence of polio and, now, the Ebola virus disease (EVD) outbreak in West Africa.1 The species circulating in West Africa, Zaire ebolavirus, carries the...
Rapid sequencing of RNA/DNA from pathogen samples obtained during disease outbreaks provides critical scientific and public health information. However, challenges exist for exporting samples to laboratories or establishing conventional sequencers in remote outbreak regions. We successfully used a novel, pocket-sized nanopore sequencer at a field diagnostic laboratory in Liberia during the curr...
The incidence of various ocular, CNS, and musculoskeletal complaints in the convalescent period following recovery from Ebola Virus Disease (PEVDS) has become an intense area of interest in the aftermath of the recent West Africa outbreak 2014-2015. A review of past outbreaks involving EBOV, SUDV, TAFV, and BDBV revealed similar, but poorly documented symptoms in the convalescent period. Additi...
Surgeons in North America need to be prepared to evaluate and to operate on patients with ebola hemorrhagic fever (Ebola). In the limited literature that exists, most clinical observations include abdominal pain [1–6]. The first case of Ebola diagnosed in the United States presented with a constellation of symptoms that included abdominal pain. We can anticipate that surgeons will be consulted ...
UNLABELLED The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generat...
SUMMARY Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, ...
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