Septicemia is a growing problem among low birth weight infants. Early identification and treatment of sepsis in these infants would help to reduce the high mortality and morbidity seen with this disorder. Newer techniques may make earlier diagnosis a reality. In the following review article, early-onset sepsis in the premature infant is described, specifically focusing on the neonatal inflammat...

PURPOSE OF REVIEW Sepsis requires prompt recognition and aggressive therapy; early goal-directed therapy decreases morbidity and mortality. Recommendations on the specific management of pediatric sepsis have historically been extrapolated from adult literature and from expert/consensus opinion. This review serves to appraise recent recommendations and determine the applicability of newly promot...

OBJECTIVE A periodic review of neonatal sepsis to asses any change in the infecting organism. METHOD A prospective study was conducted at HMC and ASH, Karachi. The babies suspected to have or developed sepsis any time during hospitalization were investigated to establish the diagnosis and isolate the causative organism. Blood culture was taken at the time of admission or when sepsis was suspe...

PURPOSE To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury (AKI) in sepsis-related conditions and its predictive and prognostic values. PATIENTS AND METHODS This study included 65 patients, who were clinically evaluated for sepsis, severe sepsis, or septic shock, and 20 apparently healthy served as controls. Patients were divided ...

Background: Sepsis, defined as the systemic inflammatory response syndrome that occurs during infection, is generally viewed as a disease aggravated by the inappropriate immune response encountered in the affected individual. HMG-CoA reductase inhibitors are potentially powerful inhibitors of the inflammatory process by a lipid independent mechanism as they are not related to lowering LDL chole...

Among the different conditions of critical illness leading to admission to an Intensive Care Unit (ICU), sepsis remains the leading cause of death at the non-coronary medical ICU [1]. Even with optimal therapy, mortality rates of severe sepsis and septic shock are about 40 to 50% [2, 3]. Although there are numerous studies with varying methods from different countries, the incidence of severe s...

RATIONALE Ecthyma gangrenosum (EG) is an aggressive cutaneous disease caused by local or systemic infection with Pseudomonas aeruginosa. EG is characterized by cutaneous manifestations ranging from nodule and papule, to necrotic ulceration with surrounding erythema, especially with black eschar or central crust. EG presents with characteristic skin lesions which is important to establish diagno...

Quantification of IgM molecular response by droplet digital PCR as a potential tool for the early diagnosis of sepsis Eduardo Tamayo, Raquel Almansa, Elena Carrasco, Ana Ávila-Alonso, Ana Rodríguez-Fernández, John Wain, María Heredia, Esther Gomez-Sanchez, Susana Soria, Lucia Rico, Verónica Iglesias, Ángel Martínez-Martínez, David Andaluz-Ojeda, Jose Ignacio Gómez Herreras, Jose Maria Eiros and...

PURPOSE The aim of this study was to explore the risk factors, clinical symptoms, hematological parameters, causative pathogen and antibiotic susceptibility of neonatal sepsis in a Chinese NICU. METHODS A retrospective survey was conducted on 116 cases of neonatal sepsis in NICU at the Maternal and Child Care Hospital in Shenzhen, China from January 2009 to December 2012. Patients were divide...

Neonatal sepsis is a major cause of death in newborns despite sophisticated neonatal intensive care. This retrospective study reviewed the clinical characteristics of cases of culture-proven sepsis in a neonatal intensive care unit from January 1992 to December 2001. Patients were divided into those with onset of sepsis in the first 7 days of life (early-onset group) and those with onset after ...