BACKGROUND The homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons. METHODOLOGY/PRINCIPAL FINDINGS We have investigated the role of Prox1 in the developing mouse ear taking advantage of available standard and conditional Prox1 mutant mouse strains using Tg(Pax2-Cre) and Tg(Nes-Cre)....

In a previous study we reported difficulty with expressive language and visuoperceptual ability in preschool children with epilepsy and otherwise normal development. The present study analysed speech and language dysfunction for each individual in relation to epilepsy variables, ear preference, and intelligence in these children and described their auditory function. Twenty 6-year-old children ...

The response of attention systems to emotional stimuli has been intensively investigated in the visual modality. Several findings suggest that neural mechanisms influencing selective attention towards emotional stimuli involve brain systems that are partly independent of cortical networks associated with the control of voluntary attention. To test this hypothesis in the auditory modality, we us...

In dichotic listening, two similar, yet different stimuli are presented simultaneously to the left and right ear. When two syllables are presented in this way, they seem to blend and discrimination of syllables presented to one ear is only possible with uncertainty. In this event-related fMRI study, we found that the orbitofrontal and paralimbic belts were involved in target detection in dichot...

Our last cases of cochlear implants in obliterated or ossified cochleas are presented, and we had described the surgical technique for double-array or compressed system. In our opinion the best surgical method is the combined approach (endoaural with aticotomy view and posterior timpanotomy) for increased promontory view. This technique provides the advantage that it always preserve the posteri...

The use of bone-anchored hearing aids is not possible for all patients who wear an implant-retained auricular prosthesis. For some patients, the external ear canal cannot be occluded with a conventional hearing device. Currently manufactured hearing aids may not readily fit the contours of an implant-retained auricular prosthesis. This article describes a technique that allows a modular hearing...

objectives: all subjects suspected of central auditory processing disorder (capd) were previously tested by free recall dichotic digits test (ddt). the study objective was normalization and reliability evaluation of two-pair ddt in 750 native persian subjects aged 8 to 12 years. materials: a total of 750 subjects were divided into five age groups varying between 8 years and 12 years and 11 mont...

There was studied the possibility of reducing effect weather conditions on spring wheat productivity in Non-Blackearth zone due to improving tillage technologies. has been established that soddy-podzolic light loamy soil, fields Ivanovsky Research Institute Agriculture period 2013–2019, difference number productive stems per m2 when using plowing or minimal not significant HTC changed from 0.73...

Dichotic listening procedures have been used to assess cerebral lateralization in normal subjects. One particularly useful technique is the use of stimuli that fuse into a single percept. Although this procedure has many advantages over other dichotic listening methods, it is particularly susceptible to stimulus dominance, which acts as noise in a subject's response data, thus reducing the powe...

objectives: microtia is the most commonly seen congenital ear defect, and involves an auricular deformity either unilaterally or bilaterally. the aim of this study was to fabricate silicone prostheses for a child with bilateral microtia using an innovative technique. methods: this method involved the construction of bilateral ear prostheses using clips, which were located within the layers of t...