نتایج جستجو برای: e7 gene

تعداد نتایج: 1144086  

Journal: :Cellular Microbiology 2022

Purpose. Evaluate if human papillomavirus (HPV) infection in lung cancer patients might be helping development by altering p16, p21, and PCNA, key genes involved cell proliferation tumor development. Methods. 63 fresh-frozen (FF) formalin-fixed paraffin-embedded (FFPE) samples from were used to detect HPV PCR, followed genotype through sequencing. The host gene expressions of PCNA quantified qP...

Journal: :Journal of virology 2001
R W Tindle K Herd T Doan G Bryson G R Leggatt P Lambert I H Frazer M Street

The E7 oncoprotein of human papillomavirus 16 (HPV16) transforms basal and suprabasal cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which immunotherapeutic strategies aimed at cytotoxic T-lymphocyte (CTL) induction are currently directed. By quantifying major histocompatibility complex class I tetramer-binding T cells and CTL in mice expressing an HPV16 E7 ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Benyue Zhang Wei Chen Ann Roman

High-risk human papillomaviruses (HPVs) (e.g., HPV-16) cause anogenital and head and neck cancers, and low-risk HPVs (e.g., HPV-6) cause benign hyperproliferative disease. The E7 protein of HPV-16 binds all retinoblastoma tumor suppressor protein (pRB) family members with higher affinity than HPV-6E7. The HPV-16 E7 protein has been reported to target pRB family members for degradation and to im...

Journal: :Journal of immunology 2004
Xiaohui Peng S Farzana Hussain Yvonne Paterson

Previous work from our laboratory has shown that Lm-LLO-E7 induces complete regression of approximately 75% of established TC-1 tumors, whereas Lm-E7 only slows the growth of such tumors. In this study, we examine the effects of Lm-LLO-E7 vs Lm-E7 on APCs. We hypothesize that the difference in antitumor efficacy of the two vaccines is due to the ability of each of these vectors to render immatu...

Journal: :Journal of the National Cancer Institute 2004
Boudewijn J M Braakhuis Peter J F Snijders Willem-Jan H Keune Chris J L M Meijer Henrique J Ruijter-Schippers C René Leemans Ruud H Brakenhoff

BACKGROUND Transcriptionally active high-risk human papilloma viruses (HPVs), particularly HPV type 16 (HPV16), are found in a subset of head and neck squamous-cell carcinomas (HNSCCs). HPV16-associated carcinogenesis is mediated by expression of the viral E6 and E7 oncoproteins, which cause deregulation of the cell cycle by inactivating p53 and pRb, respectively. We tested the hypothesis that ...

2006
I. H. Frazer D. M. Leippe L. A. Dunn A. Liem R. W. Tindle G. J. P. Fernando W. C. Phelps P. F. Lambert

The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the development of cervical cancers in women infected with certain HPV genotypes, most notably HPV-16 and HPV-18. Given their expression in tumor tissue, E6 and E7 have been implicated as potential tumor-specific antigens. We have examined an HPV-16 E6and E7-transgenic mouse lineage for immune responses to these ...

Journal: :Journal of immunology 2001
I H Frazer R De Kluyver G R Leggatt H Y Guo L Dunn O White C Harris A Liem P Lambert

Mice transgenic for the E7 tumor Ag of human papillomavirus type 16, driven from a keratin 14 promoter, express E7 in keratinocytes but not dendritic cells. Grafted E7-transgenic skin is not rejected by E7-immunized mice that reject E7-transduced transplantable tumors. Rejection of recently transplanted E7-transgenic skin grafts, but not of control nontransgenic grafts or of established E7-tran...

Journal: :Microorganisms 2023

Cervical cancer is associated with persistent infections by high-risk Human Papillomavirus (HPV) types that may have nucleotide polymorphisms and, consequently, different oncogenic potentials. Therefore, this study aimed to evaluate the genetic variability and structural effects of E7 oncogene HPV58 in cervical scraping samples from Brazilian women. The was developed patients hospitals metropol...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994
D A Greenhalgh X J Wang J A Rothnagel J N Eckhardt M I Quintanilla J L Barber D S Bundman M A Longley R Schlegel D R Roop

In order to create a transgenic model for human papilloma virus (HPV)-associated carcinogenesis, we have used the regulatory elements of a human keratin K1 (HK1) gene to target the expression of the E6 and E7 oncogenes of HPV-18 exclusively to the epidermis. All murine expressors were viable and lived normal lifetimes; older mice (> 1 year) possessed numerous small lesions with a verrucous (war...

Journal: :Cancer research 2004
Françoise Thierry Mohammed Abderrafi Benotmane Caroline Demeret Marcella Mori Sébastien Teissier Christian Desaintes

More than 90% of cervical carcinomas are associated with human papillomavirus (HPV) infection. The two viral oncogenes E6 and E7 play a major role in transforming the cells by disrupting p53- and pRb-dependent cell cycle checkpoints. A hallmark of HPV-associated cervical carcinoma is loss of the expression of the viral E2 protein, often by disruption of E2-encoding gene. We showed previously th...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید