نتایج جستجو برای: e2fs

تعداد نتایج: 164  

Journal: :Environmental Health Perspectives 1996
Yingchun Liu Markus Ringnér

Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation results in an observed expression signature. We present a stra...

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2013
Monika Verma Sandeep Singh Smitha Pillai Dongyu Zhang Daniele Pernazza Said M. Sebti Nicholas J. Lawrence Barbara A. Centeno Srikumar P. Chellappan

Inactivation of the retinoblastoma (Rb) tumor suppressor protein is widespread in human cancers. Inactivation of Rb is thought to be initiated by association with Raf-1 (C-Raf) kinase, and here we determined how RRD-251, a disruptor of the Rb–Raf-1 interaction, affects pancreatic tumor progression. Assessment of phospho-Rb levels in resected human pancreatic tumor specimens by immunohistochemis...

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2012
Brandon N. Nicolay Nicholas J. Dyson

E2F is one of the best-known cell cycle– dependent transcription factors. The family of E2F proteins have been highly conserved during evolution and function as both transcriptional activators and repressors. In most animals, E2F-mediated activation is a key driver of cell proliferation, and deregulation of E2F is found in most types of cancers. In addition to its proliferation-promoting proper...

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2004
Peggy J. Farnham

The retinoblastoma (Rb) protein is a key regulator of cell proliferation, differentiation, and tumorigenesis. Initial studies of Rb revealed that it binds to, and decreases the activity of, the E2F family of transcription factors. Over the last decade, the mechanisms by which Rb regulates E2F activity have been well-studied. These investigations have lead to a commonly held belief that Rb funct...

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