E1, along with E(rns) and E2 is one of the three envelope glycoproteins of Classical Swine Fever Virus (CSFV). Previously we showed that glycosylation status of virulent CSFV strain Brescia E2 or E(rns) affects virus virulence. Here, the three putative glycosylation sites of E1 were serially removed by means of site directed mutagenesis of a CSFV Brescia infectious clone (BICv) and their effect...

Uses Background Concentrations Environmental Chemistry General Chemical Properties Mode of Action Fate in Soils and Water Lethal and Sublethal Effects General Terrestrial Plants and Invertebrates Aquatic Organisms Birds Mammals Recommendations Acknowledgments References Tables Number 1 Paraquat concentrations in field collections of selected organisms and nonbiological materials 2 Chemical and ...

An element is known a strongly nil* clean if a=e1 - e1e2 + n , where e1,e2 are idempotents and nilpotent, that commute with one another. ideal I of ring R called each element. We investigate some its fundamental features, as well relationship to the nil ideal.

Random mutagenesis of human papillomavirus type 16 (HPV16) E1 was used to generate E1 missense mutants defective for interaction with either hUBC9 or 16E1-BP, two cDNAs encoding proteins that have been identified by their ability to interact with HPV16 E1 in two-hybrid assays. hUBC9, the human counterpart of Saccharomyces cerevisiae UBC9, is a ubiquitin-conjugating enzyme known to be involved i...

OBJECTIVE Exocrine pancreatic function in patients with cystic fibrosis (CF) can be evaluated by direct and indirect tests. In pediatric patients, indirect tests are preferred because of their less invasive character, especially in CF patients with respiratory disease. Fecal tests are noninvasive and have been shown to have a high sensitivity and specificity. However, there is no comparative st...

Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers. Consequently, developing inhibitors of the ubiquitination system for the treatment of cancer has been a recent area of interest. Currently, only a few classes of compounds have been discovere...

Let G be a graph with vertex set V(G) and edge E(G), let d(u,w) denote the length of u−w geodesic in G. For any v∈V(G) e=xy∈E(G), d(e,v)=min{d(x,v),d(y,v)}. distinct edges e1,e2∈E(G), R{e1,e2}={z∈V(G):d(z,e1)≠d(z,e2)}. Kelenc, Tratnik Yero [Discrete Appl. Math. 251 (2018) 204-220] introduced notion an resolving dimension graph: A subset S⊆V(G) is if |S∩R{e1,e2}|≥1 for dimension, edim(G), minimu...

Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreatic cancer and the expression of hnRNP E1 and integrin β1 was evaluated. In vitr...

Environmental endocrine-disrupting compounds (EDCs) are a growing concern as studies reveal their persistence and detrimental effects on wildlife. Microorganisms are known to affect the transformation of steroid EDCs; however, the diversity of estrogen-degrading microorganisms and the range of transformations they mediate remain relatively little studied. In mesocosms, low concentrations of add...