Immunotherapy with monoclonal antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) or programmed cell death 1 (PD-1) has improved the survival of patients with metastatic melanoma. These agents carry a certain risk of adverse immune-related events. We present a patient with widely metastatic melanoma who was initially treated with ipilimumab and subsequently with nivolumab. After four...

Recently, so-called Fuchsian codes have been proposed in [I. BlancoChacón et al., “Nonuniform Fuchsian codes for noisy channels”, J. of the Franklin Institute 2014] for communication over channels subject to additive white Gaussian noise (AWGN). The two main advantages of Fuchsian codes are their ability to compress information, i.e., high code rate, and their logarithmic decoding complexity. I...

We consider a totally nonsymplectic (TNS) Anosov action of Zk which is either uniformly quasiconformal or pinched on each coarse Lyapunov distribution. We show that such an action on a torus is C∞–conjugate to an action by affine automorphisms. We also obtain similar global rigidity results for actions on an arbitrary compact manifold assuming that the coarse Lyapunov foliations are topological...

E-mail brings us lots of conveniences. Especially with help of PGP and S/MIME, it gives both confidentiality and message/origin authentication. However, in some cases for strong privacy, a message sender will not want to let others know even the fact that he sent a message to a recipient. Very recently, Harn and Ren proposed a fully deniable authentication scheme for E-mail where a sender can r...

This paper proposes a new ecient signature scheme from bilinear maps that is secure in the standard model (i.e., without the random oracle model). Our signature scheme is more eective in many applications (e.g., blind signatures, group signatures, anonymous credentials etc.) than the existing secure signature schemes in the standard model such as the Boneh-Boyen [6], Camenisch-Lysyanskaya [10],...