The novel racemic secondary alcohol (±)-2-{[4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol (12) has been successfully synthesized through S-alkylation of 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazole-3-thiol (10) in alkaline medium with 2-bromo-1-phenylethanone followed by reduction the corresponding ketone 11. All compounds were characterized IR, 1D (1H, 13C, DEPT...

The development of nuclear magnetic resonance (NMR) spectroscopy as an established research tool for noninvasive studies of cancer cells and for in vivo studies of tumors in animals and humans has led to the possibility that this technique may be used in the future for clinical research studies and monitoring of therapy in cancer patients in combination with magnetic resonance imaging. This art...

In the last 15 years NMR has become a reference technique for the determination of purity for organic standards containing NMR active nuclei [1, 2]. The puzzle proposed for this Analytical Challenge was focused on the use of 1H-NMR for the characterization of a phenylbutazone standard. Such material was purchased from Sigma-Aldrich and analyzed in parallel by HPLC-UV and 1H-NMR. Initially, appl...

Bu çalışmada, 2-((1H-indol-1-il)(naftalen-1-il)metil)fenol bileşiği ilk kez sentezlenmiş olup, yapısal analizi 1H-NMR, 13C-NMR, FT-IR gibi spektroskopik yöntemlerle deneysel ve teorik olarak incelenmiştir. Bileşiğe ait birçok özellik; spektral veriler, bağ uzunluğu, açısı, dihedral açıları, molekül yüzeyi, FMO doğrusal olmayan optik (NLO) özellikleri de araştırılmıştır. Hesaplamalar; HF DFT/B3L...

in this paper, new (2e, 2'e)-3, 3'-(((3- hydroxypropane-1, 2-diyl) bis (oxy)) bis (2, 1-phenylene)) bis (1-phenylprop-2-en-1-one) (2a) was prepared in good yield by condensation reaction of acetophenone with bisaldehyde (1a) in ethanolic naoh solutions at room temperature. the (2e, 2'e)-3, 3'-(((3- hydroxypropane-1, 2-diyl) bis (oxy)) bis (2, 1-phenylene)) bis (1-phenylprop-...

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...

Two novel urea anion receptors (11) and (12) were synthesized from building block 3,3’ methylene diamine and was characterized via the techniques of 1H NMR, 13 C NMR, DEPT135 1H-1H COSY, HMQC and HMBC spectroscopy. The 1H NMR profile of both compounds reveals diagnostic peaks. For compound (11), the urea NH protons resonate as two singlets downfield at 8.706 ppm and 8.635 ppm, whereas for compo...

Footrot is a debilitating and contagious disease in dairy cows, caused by the Gram-negative anaerobe Dichelobacter nodosus. 1H-NMR (nuclear magnetic resonance)-based metabolomics has been previously used to understand the pathology and etiology of several diseases. The objective of this study was to characterize serum from dairy cows with footrot (n=10) using 1H-NMR-based metabolomics and chemo...

BACKGROUND The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS Metabolomic profiling, employing 1H-NMR, 1H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared wit...