Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement i...

Objective: To investigate the number of intra-epithelial lymphocytes in the duodenal mucosal biopsies of patients with non specific duodenitis, clinically labelled cases of celiac disease and in normal duodenal mucosa. Material and Methods: The study included three groups. A total of 73 duodenal biopsies received in the department of histopathology, PIMS (Pakistan Institute of Medical Sciences)...

BackgroundEosinophilic gastritis and/or eosinophilic duodenitis (EG/EoD) is characterized by persistent symptoms and elevated eosinophils in the gastrointestinal tract. Limited disease awareness lack of diagnostic guidelines suggest that patients may remain undiagnosed or endure delay.ObjectiveTo characterize path to diagnosis for with EG/EoD a representative population.MethodsIn this observati...