Abstract Introduction Narcolepsy type 1 (NT1) is caused by selective loss of orexinergic neurons. Although narcolepsy typically begins in childhood or adolescence, most mouse models induce the orexin peptides neurons from birth. To generate a model that reflects acquired human NT1, we produced recombinant mice expressing diphtheria toxin receptor (DTR) driven prepro-orexin promoter (orexinDTR m...

Combination of doxorubicin (DOX) and docetaxel (DTX) is clinically effective against many drug-refractory cancers, nevertheless, enhanced side effects, e.g. cardiotoxicity related to oxidative damage of tissue macromolecules is observed. Nitroxides represent an attractive class of synthetic compounds to ameliorate DOX-DTX toxicity in non-targeted tissues due to their antioxidant and iron-oxidiz...

This paper gives a brief description about some routing protocols like EEE LEACH, LEACH and Direct Transmission protocol (DTx) in Wireless Sensor Network (WSN) and a comparison study of these protocols based on some performance matrices. Addition to this an attempt is done to calculate their transmission time and throughput. To calculate these, MATLAB environment is used. Finally, on the basis ...

For the first time the presence of dinophysistoxin-1 (DTX-1) in a culture of Prorocentrum foraminosum was revealed in cells and in the culture medium. The clone was isolated from coastal waters of the Sea of Japan and identified by molecular analyses of SSU and D1/D2 regions of LSU rDNA. The concentration of DTX-1 in cells was 8.4 ± 2.5 pg/cell and, in cell-free media, 27.9 ± 14.7 µg/L. The tox...

Okadaic acid (OA) and its analogues cause diarrhetic shellfish poisoning (DSP) in humans, risk assessments of these toxins require toxicity equivalency factors (TEFs), which represent the relative toxicities analogues. However, no human death by DSP toxin has been reported, current TEF value is based on acute lethality. To properly reflect symptoms DSP, such as diarrhea without death, chronic a...

You have accessJournal of UrologyLate-breaking Abstract II - Malignant1 Sep 2021LBA02-11 MASITINIB PLUS DOCETAXEL AS FIRST-LINE TREATMENT OF METASTATIC CASTRATE REFRACTORY PROSTATE CANCER: RESULTS FROM STUDY AB12003 Michel Pavic, Olivier Hermine, and Dominique Spaeth PavicMichel Pavic More articles by this author , HermineOlivier Hermine SpaethDominique View All Author Informationhttps://doi.or...

A novel electrochemical immunosensor for the detection of important marine biotoxins domoic acid (DA) and okadaic (OA) was developed. The sensors used carbon black modified screen-printed electrodes (CB-SPE) obtained using a high-throughput method. performance stability CB SPEs bare (c-SPEs) were compared cyclic voltammetry impedance spectroscopy. CB-SPEs showed improved long-term (at least six...

Accumulation and retention of regulatory T-cells (Tregs) has been reported within post viral-encephalitic brains, however, the full extent to which these cells modulate neuroinflammation is yet to be elucidated. Here, we used Foxp3-DTR (diphtheria toxin receptor) knock-in transgenic mice, which upon administration of low dose diphtheria toxin (DTx) results in specific deletion of Tregs. We inve...