BACKGROUND Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). OBJECTIVE To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is ...

Fifty-nine patients with ureteric obstruction were divided into 2 groups, determined by the severity of the insult received by the affected kidney. In each renogram the slope of the second phase of the curve of the affected kidney was expressed as a percentage of that of the normal kidney, and termed the 'function index'. The transit time for the affected kidney was expressed as a multiple of t...

angle. Intravenous and retrograde pyelography showed a filling defect in the renal pelvis, and the isotope renogram suggested impaired renal function. A definitive diagnosis was only made after renal angiography. It is thought in this case that the carcinoma must have caused the haematuria previously investigated and probably at that stage caused radiological changes which were mistaken as bein...

Introduction: A promising myeloperoxidase-sensing MRI agent, bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium [bis5HT-DTPA(Gd)] has been recently used for magnetic resonance imaging of in vivo myeloperoxidase (MPO) activity. In the presence of MPO, bis-5HT-DTPA(Gd) can be radicalized to form oligomers and bind to matrix proteins, resulting in increased spin-lattice relaxation ...

Fingerlings (0.23 g) and juveniles (267.04 of African catfish (Clarias gariepinus) were reared for 32 days under experimental aquarium conditions exposed to either 0.75 mg/L or 3.0 diethylenetriaminepentaacetic acid-iron(II) (Fe-DTPA) 12.0 Fe-DTPA in the water, respectively. These treatment groups compared a control group without additional Fe-DTPA. The growth, mortality, ethological indicators...

PURPOSE To evaluate the utility of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in characterizing atypically enhanced cirrhotic nodules detected on conventional Gd-DTPA-enhanced MR images. MATERIALS AND METHODS We enrolled 61 consecutive patients with 88 atypical nodules seen on conventional Gd-DTPA-enhanced MR images who underwent Gd-EOB-DTPA-enhanced MRI within a 3-month period. Us...

OBJECTIVES The main goal was to gain insights into the pharmacokinetics of intrapericardial drug delivery using magnetic resonance (MR) imaging analysis and the extracellular MR contrast agent gadopentetate dimeglumine (Gd-DTPA) as a model. BACKGROUND Recent development of catheter-based techniques to access the intact pericardial space has increased interest in intrapericardial delivery for ...

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their efficacy. Non-covalent interactions lead to complex formation that can be quantified by several techniques that are mostly tedious and time-consuming. In this study, electrospray ionization mass sp...

OBJECTIVE The aim of this study was to compare the renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured using 99mTc-DMSA static scintigraphy. METHODS the values of relative renal function measured in 111 renal dynamic scintigraphies performed either with 99mTc-DTPA (55 studies) or with 99mTc-EC (56 studies) were compared with the relative functi...