A novel inorganic-organic hybrid supramolecular macrocyclic compound, (4-nitroanilinium) (18-crown-6)(PF6)(1), was synthesized and characterized by infrared spectroscopy, thermogravimetric analysis, elemental analysis, differential scanning calorimetry (DSC), and single-crystal X-ray diffraction. Crystal 1 is found to comprise 1D C–H···F–P hydrogen-bonded chains of (4-nitroanilinium+) (18-crown...

(2015) Combination of (M)DSC and surface analysis to study the phase behaviour and drug distribution of ternary solid dispersions. The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. A note on versions: The version presented here may differ from the published version or from the version of record. If...

Supervisors: Dr. László Hunyady, DSc, professor Dr. András Balla, PhD, associate professor Official reviewers: Dr. Károly Liliom, PhD, senior research fellow Dr. Attila Reményi, PhD , senior research fellow Head of the Final Examination Committee: Dr. Zsuzsanna Fürst, DSc, professor emerita Members of the Final Examination Committee: Dr. Szabolcs Sipeki, PhD, senior lecturer Dr. Beáta Sperlágh,...

1 Ivona Đurkin, BScAgr, Assistant; Goran Kušec, DSc, Associate Professor; Gordana Kralik, DSc, Full Professor; Antun Petričević, DSc, Prof. Emeritus; V. Margeta, MSc, Junior Assistant; Danica Hanžek, BSc Agr, Expert Consultant; Zlata Maltar, MSc, Expert Consultant. Faculty of Agriculture, University J. J. Strossmayer in Osijek, Department of Special Zootechnics, Trg Sv. Trojstva 3, 31 000 Osije...

The aim of this research was to evaluate solid state interaction between amoxicillin trihydrate and potassium clavulanate. The interaction was observed by Differential Scanning Calorimeter (DSC), X-Ray Powder Diffractometer (XRPD), Fourier Transforms Infra Red (FTIR) and Scanning Electron Microscope (SEM). Mixtures of amoxicillin trihydrate and potassium clavulanate were prepared in molar ratio...

OBJECTIVE Arterial spin-labelling (ASL) MRI uses intrinsic blood water to quantify the cerebral blood flow (CBF), removing the need for the injection of a gadolinium-based contrast agent used for conventional perfusion imaging such as dynamic susceptibility contrast (DSC). Owing to the non-invasive nature of the technique, ASL is an attractive option for use in paediatric patients. This work co...

Antimycotic bifonazole (BIF) is a very hydrophobic compound, which is a major drawback for obtaining topical pharmaceutical formulations with optimal bioavailabiliy and for the penetration into hydrophilic human nail matrices. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and β-cyclodextrin were prepared in ...

BACKGROUND Microbial synthesis of oleochemicals derived from native fatty acid (FA) metabolism has presented significant advances in recent years. Even so, native FA biosynthetic pathways often provide a narrow variety of usually linear hydrocarbons, thus yielding end products with limited structural diversity. To overcome this limitation, we took advantage of a polyketide synthase-based system...

Non-steroidal anti-inflammatory drugs have an important impact in the actual medicinal therapy, having indications in covering the range from rheumatic inflammations to cardio-vascular, genito-urinary and stomatological diseases. Flufenamic acid is a nonsteroidal anti-inflammatory drug, from the class of fenamates. It exhibits poor aqueous solubility, accordingly the aim of this study was to en...

BACKGROUND Prostate bed (PB) contouring is time consuming and associated with inter-observer variability. We evaluated an automated atlas-based segmentation (AABS) engine in its potential to reduce contouring time and inter-observer variability. METHODS An atlas builder (AB) manually contoured the prostate bed, rectum, left femoral head (LFH), right femoral head (RFH), bladder, and penile bul...