The treatment of inflammatory arthritis has been revolutionised by the introduction biologic treatments. Many agents are currently licensed for use in both paediatric and adult patients with contribute to improved disease outcomes compared pre-biologic era. However, immunogenicity agents, characterised an immune reaction leading production anti-drug antibodies (ADAs), can negatively impact ther...

The main problems in cancer chemotherapy are related to the fact that the available drugs are not specific nor selective enough in their anticancer action. Therefore, even a low degree of resistance at the target tumor level is sufficient to impart clinical resistance because the dose of drug cannot be increased sufficiently to overcome it without incurring unacceptable toxicity. In the face of...