An 86-year-old man, admitted for transarterial chemoembolization of a hepatoma, developed fever and acute renal failure following the procedure. He was given antibiotic therapy and oral calcium polystyrene sulfonate (30g daily) for hyperkalemia. After 1 week, the patient developed bilious vomiting with abdominal pain. An abdominal X-ray disclosed diffuse dilatation of the small bowel (●" Fig.1)...

This study investigates fracture behaviour of sandwich structures with foam core slits. These slits are typically machined in the materials to improve manufacturability but inevitably lead material discontinuities such as resin-starving regions or voids. Using phase-field method, which does not require exact location crack initiation path known a prior, complex process different resin-filling i...

Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the naturally occurring resin acid dehydroabietic acid (DHAA) is a potent opener of a voltage-gated K channe...

In this study, Damar Batu (DB) − a novel biomaterial− is evaluated for its potential application in pharmaceutical coating. DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB are investigated for mechanical, water vapor transmission...

the effect of different kinds of surfactants in various concentrations incorporated in an inert matrix, on the release of procainamide hydrochloride, as a cationic model compound, was investigated in this study. sodium lauryl sulfate and sodium stearate as anionic surfactants, cetyl pyridinium chloride and cetyltrimethyl ammonium bromide as cationic and span 60 and tween 80 as non-ionic surfact...

Glass fiber reinforced Polymer matrix composites (PMCs) have a complex set of properties - high specific strength and hardness, good corrosion chemical resistance, most all low relative weight, making them the preferred material over metallic materials in number industries (aircraft, boat building, renewable energy facilities many others). The main aim present work was reduced to obtaining PMCs...

B in 1956, American artist Fred Tomaselli grew up in Orange, California, and in 1982, he graduated from California State University, Fullerton, with a degree in painting and drawing. In the early 1980s, Tomaselli became established in the “Downtown L.A.” art, music, and drug countercultures. Since 1985, he has lived and worked in Brooklyn, New York. He is best known for his visually stunning hy...

Dichlorodiammineplatinum(ll) is an anti-neoplastic agent that is currently undergoing clinical evaluation. We describe an analytical method for monitoring the free drug (or its breakdown products) in plasma. The method is able to distinguish between free and protein-bound drug. Plasma samples are deproteinized by centrifugal ultrafiltration. The platinum in the ultrafiltrate is converted to a c...

[reaction: see text] We describe the diastereoselective synthesis of a pharmaceutically active drug candidate via a column-based system. This methodology is complementary to classical solid-phase synthesis; individual columns are packed with resin-bound reagents and then linked in sequence and/or in parallel. In contrast to the traditional solid-phase approach, substrates are introduced in the ...