Objective: To evaluate the effect of NIPRD-AM1 on CYP3A4 in order to generate clinically significant data for its safe and efficacious use. Materials and Methods: NIPRD-AM1 is a phytomedicine developed from aqueous root extracts of Nauclea latifolia Smith (Rubiaceae) for the treatment of uncomplicated malaria. The effect of NIPRD-AM1 on CYP3A4 was measured with and without the addition of NIPRD...

Mycobacterium is acid fast genus of bacteria that include many pathogenic and non pathogenic species. Treatment is made quite difficult by the presence of metabolically silent, persistent or dormant bacteria within host lesions, which are not susceptible to the anti-mycobacteria drugs that usually kill growing bacteria but not persistent mycobacteria. The emergence of antibiotic resistance stra...

Clopidogrel is a widely-used antiplatelet drug. It important for the treatment and prevention of coronary heart disease. can effectively reduce platelet activity therefore stent thrombosis. However, some patients still have ischemic events despite taking clopidogrel due to alteration in metabolism attributable various genetic non-genetic factors. This review aims summarise mechanisms causes res...

Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA (W.L., B.F.L., R.B.K.) and Department of Drug Metabolism, Merck Research Laboratories, West Point, PA, USA (P.S., X.X., M.Y., J.A.S., J. H. L., P.G.P). *Current address: Department of Drug Safety and Metabolism, Wyeth Pharmaceuticals, 1 Burtt Road, Andover, MA 01810 **Current address: Department of P...

Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC 27709 (J.R., J.E.H., L.O.W., A.B., C.J.S.S., J.W.P.), Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Ware, UK (J.P.K.); Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, PA 19406 (J.R.K.); and Department of Pharmaceutical Chemistry, University of Kuo...