Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and...

The purpose of this study was to find a multilamellar liposomal formulation for the antichagasic drug Benznidazole (BNZ). Different lipid matrices and organic solvents for BNZ were tested in order to obtain the liposomes with the highest g BNZ/100 g total lipid (D/TL) ratio. The best lipid matrices resulted from hydrogenated phosphatidylcholine from soybean (HSPC): Cholesterol (Chol): distearoy...

Copyright: © 2013 Salerno C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Supramolecular assembly into tubular micro and nanostructures has been a field of much interest lately. Lipid-based microtubes...

MUC-1 aptamer-amphiphiles were used to functionalize DPPC liposomes to create nanoparticles. Various properties of the targeted liposomes drug delivery vehicles were examined including their drug-to-lipid ratio (DL), targeted ligand insertion efficiency (IE), and stability. The ratio of lipid and MUC-1 aptamer-amphiphile in the liposomes was varied to determine this ratio’s influence on liposom...

An antileukemic phthalanilide, 2-chloro-4',4"-di(2-imidazolin2-yl)terephthalanilide (NSC 60339), was taken up by P388 lymphocytic leukemia cells growing in culture. The uptake was related to the extracellular concentration of drug and the length of exposure to drug. The drug was extracted from the cells in 3 forms: lipid-bound, hydrophilic-bound, and "free." The levels of both bound components ...