Synergistic drug combinations enable enhanced therapeutics. Their discovery typically involves the measurement and assessment of drug combination index (CI), which can be facilitated by the development and applications of in-silico CI predictive tools. In this work, we developed and tested the ability of a mathematical model of drug-targeted EGFR-ERK pathway in predicting CIs and in analyzing m...

Recently, drug combination therapies provide a promising strategy in treating cancer by inhabiting redundant pathways simultaneously [1]. Drug combination screening in the cancer cell models is often utilized as a starting point to prioritize the most potential hits for further experimental investigation and therapy optimization [2]. To facilitate the drug combination discovery, high-throughput...

antiepileptic drugs combination therapy and interactions antiepileptic drugs combination therapy and interactions this page intentionally left blank chuyên khoa than antiepileptic drugs combination therapy and interactions josé e. cavazos, md phd san antonio va epilepsy center of 40 combination therapy in epilepsy : what, when, how and the importance of drug interactions in epilepsy therapy dru...