BACKGROUND Folate is involved in DNA synthesis and methylation and may thereby influence carcinogenesis. OBJECTIVES We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C-->T (rs1801133) and 1298A-->C (rs1801131)]. We also explored whether P-folate was associated with risk of postmenopausal ...

Human milk contains both a particulate and a soluble folate binding protein. Following solubilization of the particulate folate binding protein with 1%Triton X-100, the particulate and soluble folate binding proteins were purified 13,000-fold using pteroylglutamic acid-Sepharose as the major purification step. Each of the purified proteins gave a single band on sodium dodecyl sulfatepolyacrylam...

OBJECTIVE To assess the folate status of US women in a study of a folate-fortified oral contraceptive (OC) using the Short Folate Food Frequency Questionnaire and plasma and red blood cell (RBC) folate samples. DESIGN Sub-analysis from a multi-centre, randomised, double-blind, controlled contraceptive trial with assessments at baseline and 6 months. We calculated dietary folate equivalents (D...

Serum folate concentrations, blood counts, and antiepileptic drug concentrations were measured during 133 pregnancies of 125 women with epilepsy. There was an inverse correlation between serum folate concentrations and concentrations of phenytoin and phenobarbitone. The number of epileptic seizures during pregnancy showed no association with serum folate concentrations. No cases of maternal tis...

Renal epithelioid angiomyolipoma (REA) is a rare mesenchymal tumor. The primary choice of treatment is local treatments. There is no consensus about adjuvant treatment. Doxorubicine, dacarbazine, ifosfamide, cyclophosphamide and cisplatin were shown to be effective in some case reports We present a metastatic renal epithelioid angiomyolipoma case that was treated with doxorubicin in the first l...

Researchers are not immune to fashion. A wealth of data going back several decades relating serotonin function to the regulation of mood and the current emphasis on genetics in biological psychiatry research have resulted in an increasing number of studies relating various polymorphisms of serotonin-related genes to various types of psychopathology. The assumption behind these studies is that t...

Bioavailability of dietary folate might be impaired by the polyglutamate chain to which approximately 70% of dietary folates are bound. This chain must be removed enzymatically in the intestine before folate is absorbed as a monoglutamate. To increase formation of monoglutamate folate in vegetables, the vegetables were subjected to various processing treatments. Treatments included freezing (-1...

We report a comparative study of synthesis, characteristics and in vitro tests of two folate-conjugated gold nanoparticles (AuNP) differing in linkers and AuNP sizes for selective targeting of folate-receptor positive cancerous cells. The linkers chosen were 4-aminothiophenol (4Atp) and 6-mercapto-1-hexanol (MH) with nanoconjugate products named Folate-4Atp-AuNP and Folate-MH-AuNP. We report th...

Epidemiological and experimental evidence suggests that dietary folate may protect against colorectal carcinogenesis. The epidemiological relationship between a biochemical measure of folate status and colorectal neoplasia in a sizeable and generally healthy population does not yet appear to have been reported. We conducted a case-control study of the relationships among red cell folate, plasma...