1 Universidade Federal da Bahia, Escola de Nutrição, Departamento Ciência da Nutrição. Av. Araújo Pinho, 32, Canela, 40110-150, Salvador, BA, Brasil. Correspondência para/Correspondence to: RC RIBEIRO-SILVA. E-mail: . 2 Universidade Federal da Bahia, Faculdade de Odontologia, Departamento de Odontologia Social e Pediátrica. Salvador, BA, Brasil. Support: Fundação de Amparo à P...

Amphetamine (AMPH) inhibits uptake and causes release of dopamine (DA) from presynaptic terminals. AMPH can act on both vesicular storage of DA and directly on the dopamine transporter (DAT). To assess the relative importance of these two processes, we have examined the releasing actions of AMPH in mice with a genetic deletion of the DAT. The sequence of actions of AMPH has been determined by f...

OBJECTIVE The objective of this study has been to evaluate the performance of the primary care of Brazilian municipalities in relation to health actions and outcomes. METHODS This is an evaluative, cross-sectional research, with a quantitative approach, aimed at the identification of the efficiency frontier of the primary care in health actions and outcomes in Brazilian municipalities. Second...

By stimulating distinct receptor subtypes, dopamine (DA) exerts presynaptic and postsynaptic actions on both large aspiny (LA) cholinergic and fast-spiking (FS) parvalbumin-positive interneurons of the striatum. Lack of receptor- and isoform-specific pharmacological agents, however, has hampered the progress toward a detailed identification of the specific DA receptors involved in these actions...

This paper describes (,:LBURl DAN an implementf'd planner for problem domains in whicb tbe agent is uncertain about the initial world state and the effects of its own actions, but has sensors that allow it to improve its state of information. The system uses a probabilistir semantics to represent incomplete information, and provid('s for actions with informational as well as causal effects. The...

Following administration at subanesthetic doses, (R,S)-ketamine (ketamine) induces rapid and robust relief from symptoms of depression in treatment-refractory depressed patients. Previous studies suggest that ketamine's antidepressant properties involve enhancement of dopamine (DA) neurotransmission. Ketamine is rapidly metabolized to (2S,6S)- and (2R,6R)-hydroxynorketamine (HNK), which have an...

By February 2019, the Polish pharmaceutical industry, community and hospital pharmacies, wholesalers and parallel traders must all comply with the EU-wide Falsified Medicines Directive (FMD) legislation (2011/62/EU), to ensure that no medicinal product is dispensed to a patient without proper tracking and authentication. Here we describe how Poland is complying with the new EU regulations, the ...